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HomoloGene:55711. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SMARCA1,  H.sapiens
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
    NP_001269803.1
1070 aa
   SMARCA1,  P.troglodytes
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
    XP_003317720.1
1021 aa
   SMARCA1,  M.mulatta
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
    XP_002806437.1
1070 aa
   SMARCA1,  C.lupus
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
    XP_005642178.1
961 aa
   SMARCA1,  B.taurus
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
    NP_001178471.1
1051 aa
   Smarca1,  M.musculus
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
    NP_444353.3
1046 aa
   Smarca1,  R.norvegicus
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
    NP_001258119.1
1062 aa
   SMARCA1,  G.gallus
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
    XP_420329.2
1031 aa
   smarca1,  X.tropicalis
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
    XP_002931866.2
1034 aa
   LOC559803,  D.rerio
novel protein similar to SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (smarca5)
    NP_001093467.1
1036 aa
   Iswi,  D.melanogaster
Imitation SWI
    NP_725204.1
1027 aa
   AgaP_AGAP010700,  A.gambiae
AgaP_AGAP010700
    XP_311417.3
1026 aa
   isw-1,  C.elegans
isw-1
    NP_498468.2
1009 aa
   ISW2,  S.cerevisiae
ISW2
    NP_014948.1
1120 aa
   KLLA0F24838g,  K.lactis
KLLA0F24838g
    XP_456186.1
1062 aa
   AGOS_AFR537W,  E.gossypii
AGOS_AFR537W
    NP_986084.1
1025 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The ATPase domain of ISWI is an autonomous nucleosome remodeling machine.
Mueller-Planitz F, et al. Nat Struct Mol Biol 20, 82-9 (2013).
SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions.
Euskirchen G, et al. J Biol Chem 287, 30897-905 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DBINO (pfam13892)
  DNA-binding domain.
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
DBINO (pfam13892)
  DNA-binding domain.
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
SANT (cl17250)
  'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Smarca1 includes H.sapiens SMARCA1 and R.norvegicus Smarca1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (14 transcripts, 6 species)
Mammalia - mammals (13 transcripts, 12 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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