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HomoloGene:7659. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   RB1CC1,  H.sapiens
RB1-inducible coiled-coil 1
1594 aa
   RB1CC1,  P.troglodytes
RB1-inducible coiled-coil 1
1594 aa
   RB1CC1,  M.mulatta
RB1-inducible coiled-coil 1
1594 aa
   RB1CC1,  C.lupus
RB1-inducible coiled-coil 1
1593 aa
   RB1CC1,  B.taurus
RB1-inducible coiled-coil 1
1589 aa
   Rb1cc1,  M.musculus
RB1-inducible coiled-coil 1
1588 aa
   Rb1cc1,  R.norvegicus
RB1-inducible coiled-coil 1
1588 aa
   RB1CC1,  G.gallus
RB1-inducible coiled-coil 1
1598 aa
   rb1cc1,  X.tropicalis
RB1-inducible coiled-coil 1
1576 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Breast cancer, somatic.

Articles associated with genes and sequences of this homology group.

RB1CC1 activates the promoter and expression of RB1 in human cancer.
Ikebuchi K, et al. Int J Cancer 125, 861-7 (2009).
Mechanism of cell cycle regulation by FIP200 in human breast cancer cells.
Melkoumian ZK, et al. Cancer Res 65, 6676-84 (2005).
Regulation of focal adhesion kinase by a novel protein inhibitor FIP200.
Abbi S, et al. Mol Biol Cell 13, 3178-91 (2002).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF334 (pfam03904)
  Domain of unknown function (DUF334).
ATG11 (pfam10377)
  Autophagy-related protein 11.
SbcC (COG0419)
  ATPase involved in DNA repair [DNA replication, recombination, and repair].
COG1340 (COG1340)
  Uncharacterized archaeal coiled-coil protein [Function unknown].
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
UBL_TBK1_like (cd12219)
  Ubiquitin-Like Domain Of Human Tbk1 and similar proteins.
ATG11 (pfam10377)
  Autophagy-related protein 11.
CDC37_N (cl03951)
  Cdc37 N terminal kinase binding.
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rb1cc1 includes H.sapiens RB1CC1 and R.norvegicus Rb1cc1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (21 transcripts, 15 species)
Actinopterygii - bony fishes (14 transcripts, 6 species)
Aves - birds (4 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Insecta - insects (3 transcripts, 3 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Anthozoa - anthozoans (2 transcripts, 1 species)

Eudicotyledons - eudicots (1 transcript, 1 species)




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