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HomoloGene:37364. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ITGA4,  H.sapiens
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
    NP_000876.3
1032 aa
   ITGA4,  P.troglodytes
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
    XP_525977.2
1032 aa
   ITGA4,  M.mulatta
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
    XP_001100929.1
1032 aa
   ITGA4,  C.lupus
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
    XP_545551.3
1072 aa
   ITGA4,  B.taurus
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
    NP_777173.1
1033 aa
   Itga4,  M.musculus
integrin alpha 4
    NP_034706.3
1032 aa
   Itga4,  R.norvegicus
integrin, alpha 4
    NP_001101207.1
1036 aa
   ITGA4,  G.gallus
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
    XP_421974.3
1021 aa
   itga4,  X.tropicalis
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
    XP_002932062.2
1030 aa
   itga4,  D.rerio
integrin alpha 4
    XP_002663459.2
746 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Integrin_alpha2 (pfam08441)
  Integrin alpha.
FG-GAP (cl15299)
  FG-GAP repeat.
Integrin_alpha2 (pfam08441)
  Integrin alpha.
VCBS (cl15299)
  This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Itga4 includes H.sapiens ITGA4 and R.norvegicus Itga4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

 

 

 

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