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HomoloGene:3623. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CDK5,  H.sapiens
cyclin-dependent kinase 5
    NP_004926.1
292 aa
   CDK5,  P.troglodytes
cyclin-dependent kinase 5
    XP_519523.2
292 aa
   CDK5,  M.mulatta
cyclin-dependent kinase 5
    XP_001102523.1
292 aa
   CDK5,  C.lupus
cyclin-dependent kinase 5
    XP_005629809.1
402 aa
   CDK5,  B.taurus
cyclin-dependent kinase 5
    NP_776442.1
292 aa
   Cdk5,  M.musculus
cyclin-dependent kinase 5
    NP_031694.1
292 aa
   Cdk5,  R.norvegicus
cyclin-dependent kinase 5
    NP_543161.1
292 aa
   CDK5,  G.gallus
cyclin-dependent kinase 5
    NP_001129258.1
292 aa
   cdk5,  X.tropicalis
cyclin-dependent kinase 5
    NP_001072776.1
292 aa
   cdk5,  D.rerio
cyclin-dependent protein kinase 5
    NP_571794.1
292 aa
   Cdk5,  D.melanogaster
Cyclin-dependent kinase 5
    NP_477080.1
294 aa
   AgaP_AGAP005772,  A.gambiae
AgaP_AGAP005772
    XP_315787.4
289 aa
   cdk-5,  C.elegans
cdk-5
    NP_499783.1
292 aa
   PHO85,  S.cerevisiae
PHO85
    NP_015294.1
305 aa
   KLLA0D11990g,  K.lactis
KLLA0D11990g
    XP_453596.1
304 aa
   AGOS_AGL242C,  E.gossypii
AGOS_AGL242C
    NP_986425.2
301 aa
   pef1,  S.pombe
pef1
    NP_587921.1
288 aa
   MGG_04660,  M.oryzae
MGG_04660
    XP_003713655.1
350 aa
   NCU07580,  N.crassa
NCU07580
    XP_958274.1
337 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Association between plasma biomarkers, CDK5 polymorphism and the risk of Alzheimer's disease.
Czapski GA, et al. Acta Neurobiol Exp (Wars) 72, 397-411 (2012).
Cyclin-dependent kinase 5 in axon growth and regeneration.
Ye T, et al. Int Rev Neurobiol 105, 91-115 (2012).
Association of rs2069459 in the CDK5 gene with dyslexia in a German cohort.
Burkhardt J, et al. Psychiatr Genet 22, 307-8 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cdk5 includes H.sapiens CDK5 and R.norvegicus Cdk5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (12 transcripts, 10 species)
Mammalia - mammals (11 transcripts, 11 species)
Ascidiacea - tunicates (5 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 9 species)
Arachnida - arachnids (3 transcripts, 2 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (8 transcripts, 3 species)
Eurotiomycetes - ascomycetes (2 transcripts, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (2 transcripts, 2 species)
Liliopsida - monocots (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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