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HomoloGene:1624. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HSPA4,  H.sapiens
heat shock 70kDa protein 4
    NP_002145.3
840 aa
   HSPA4,  P.troglodytes
heat shock 70kDa protein 4
    XP_517930.2
840 aa
   HSPA4,  M.mulatta
heat shock 70kDa protein 4
    XP_001106968.1
840 aa
   HSPA4,  C.lupus
heat shock 70kDa protein 4
    NP_001041481.1
840 aa
   HSPA4,  B.taurus
heat shock 70kDa protein 4
    NP_001107664.1
840 aa
   Hspa4,  M.musculus
heat shock protein 4
    NP_032326.3
842 aa
   Hspa4,  R.norvegicus
heat shock protein 4
    NP_705893.1
840 aa
   HSPA4,  G.gallus
heat shock 70kDa protein 4
    XP_414655.2
840 aa
   hspa4,  X.tropicalis
heat shock 70kDa protein 4
    NP_989252.1
835 aa
   hspa4b,  D.rerio
heat shock protein 4b
    NP_956151.1
840 aa
   hspa4a,  D.rerio
heat shock protein 4a
    NP_999881.1
833 aa
   Hsc70Cb,  D.melanogaster
Hsc70Cb
    NP_001189103.1
836 aa
   AgaP_AGAP010331,  A.gambiae
AgaP_AGAP010331
    XP_315285.3
812 aa
   C30C11.4,  C.elegans
C30C11.4
    NP_498868.1
776 aa
   SSE1,  S.cerevisiae
SSE1
    NP_015219.1
693 aa
   KLLA0E24597g,  K.lactis
KLLA0E24597g
    XP_455059.1
694 aa
   AGOS_AGR212W,  E.gossypii
AGOS_AGR212W
    NP_986878.1
697 aa
   pss1,  S.pombe
pss1
    XP_001713060.1
720 aa
   MGG_06065,  M.oryzae
MGG_06065
    XP_003711919.1
712 aa
   NCU05269,  N.crassa
NCU05269
    XP_961759.2
726 aa
   HSP91,  A.thaliana
HSP91
    NP_178111.1
831 aa
   AT1G79920,  A.thaliana
AT1G79920
    NP_850984.4
831 aa
   Os01g0180800,  O.sativa
Os01g0180800
    NP_001042210.1
845 aa
   Os05g0181000,  O.sativa
Os05g0181000
    NP_001054812.1
853 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Mortalin mutations are not a frequent cause of early-onset Parkinson disease.
Freimann K, et al. Neurobiol Aging 34, 2694.e19-20 (2013).
Involvement of heat shock protein 70 in the DNA protective effect from estrogen.
Dong Y, et al. Am J Alzheimers Dis Other Demen 28, 269-77 (2013).
Immunohistochemical expression of heat shock protein 70 in vitiligo.
Abdou AG, et al. Ann Diagn Pathol 17, 245-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HSP70 (pfam00012)
  Hsp70 protein.
HSP70 (pfam00012)
  Hsp70 protein.
HSP90 (pfam00183)
  Hsp90 protein.
NBD_sugar-kinase_HSP70_actin (cl17037)
  Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hspa4 includes H.sapiens HSPA4 and R.norvegicus Hspa4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (68 transcripts, 33 species)
Liliopsida - monocots (21 transcripts, 9 species)
Coniferopsida - conifers (5 transcripts, 3 species)
Bryopsida - mosses (3 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Chordata
Mammalia - mammals (19 transcripts, 17 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Arthropoda
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (9 transcripts, 3 species)
Pezizomycetes - ascomycetes (2 transcripts, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (3 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

 

 

 

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