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HomoloGene:20455. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   ELANE,  H.sapiens
elastase, neutrophil expressed
267 aa
   ELANE,  P.troglodytes
elastase, neutrophil expressed
244 aa
   ELANE,  C.lupus
elastase, neutrophil expressed
282 aa
   ELANE,  B.taurus
elastase, neutrophil expressed
267 aa
   Elane,  M.musculus
elastase, neutrophil expressed
265 aa
   Elane,  R.norvegicus
elastase, neutrophil expressed
271 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Hematopoiesis, cyclic.
Neutropenia, congenital.

Articles associated with genes and sequences of this homology group.

Activity of neutrophil elastase reflects the progression of acute pancreatitis.
Novovic S, et al. Scand J Clin Lab Invest 73, 485-93 (2013).
Risk factors for bronchiectasis in children with cystic fibrosis.
Sly PD, et al. N Engl J Med 368, 1963-70 (2013).
ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology.
Horwitz MS, et al. Hematol Oncol Clin North Am 27, 19-41, vii (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tryp_SPc (cd00190)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Elane includes H.sapiens ELANE and R.norvegicus Elane.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (8 transcripts, 8 species)




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