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HomoloGene:37941. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   STX1A,  H.sapiens
syntaxin 1A (brain)
    NP_004594.1
288 aa
   STX1A,  P.troglodytes
syntaxin 1A (brain)
    XP_001146754.2
288 aa
   STX1A,  M.mulatta
syntaxin 1A (brain)
    NP_001028037.1
288 aa
   STX1A,  C.lupus
syntaxin 1A (brain)
    XP_005621021.1
308 aa
   STX1A,  B.taurus
syntaxin 1A (brain)
    NP_001077267.1
322 aa
   Stx1a,  M.musculus
syntaxin 1A (brain)
    NP_058081.2
288 aa
   Stx1a,  R.norvegicus
syntaxin 1A (brain)
    NP_446240.2
288 aa
   stx1a,  X.tropicalis
syntaxin 1A (brain)
    NP_001072191.1
288 aa
   Syx1A,  D.melanogaster
Syntaxin 1A
    NP_001189276.1
296 aa
   AgaP_AGAP007698,  A.gambiae
AgaP_AGAP007698
    XP_564525.2
290 aa
   unc-64,  C.elegans
unc-64
    NP_001022615.1
291 aa
   SSO1,  S.cerevisiae
SSO1
    NP_015092.1
290 aa
   SSO2,  S.cerevisiae
SSO2
    NP_013908.1
295 aa
   KLLA0C15961g,  K.lactis
KLLA0C15961g
    XP_452913.1
286 aa
   AGOS_AFL139W,  E.gossypii
AGOS_AFL139W
    NP_985411.1
297 aa
   psy1,  S.pombe
psy1
    NP_588053.1
284 aa
   MGG_00978,  M.oryzae
MGG_00978
    XP_003717971.1
345 aa
   NCU04244,  N.crassa
NCU04244
    XP_961235.1
335 aa
   SYP131,  A.thaliana
SYP131
    NP_187030.1
306 aa
   SYP132,  A.thaliana
SYP132
    NP_568187.1
304 aa
   Os06g0168500,  O.sativa
Os06g0168500
    NP_001056925.1
305 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Syntaxin-1a is a direct target of miR-29a in insulin-producing β-cells.
Bagge A, et al. Horm Metab Res 45, 463-6 (2013).
Association analysis of STX1A gene variants in common forms of migraine.
Tropeano M, et al. Cephalalgia 32, 203-12 (2012).
Syntaxin1A lateral diffusion reveals transient and local SNARE interactions.
Ribrault C, et al. J Neurosci 31, 17590-602 (2011).
Membrane protein sequestering by ionic protein-lipid interactions.
van den Bogaart G, et al. Nature 479, 552-5 (2011).
Dysfunction of the hypothalamic-pituitary-adrenal axis in STX1A knockout mice.
Fujiwara T, et al. J Neuroendocrinol 23, 1222-30 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SynN (cd00179)
  Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
t_SNARE (cl00152)
  Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Stx1a includes H.sapiens STX1A and R.norvegicus Stx1a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (48 transcripts, 28 species)
Liliopsida - monocots (12 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chordata
Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (11 transcripts, 7 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 8 species)
Arachnida - arachnids (3 transcripts, 1 species)
Branchiopoda - crustaceans (3 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (6 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Pezizomycetes - ascomycetes (2 transcripts, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

 

 

 

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