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HomoloGene:4338. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KMT2A,  H.sapiens
lysine (K)-specific methyltransferase 2A
    NP_001184033.1
3972 aa
   MLL,  P.troglodytes
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    XP_508792.2
3969 aa
   MLL,  M.mulatta
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    XP_001093874.2
3986 aa
   KMT2A,  C.lupus
lysine (K)-specific methyltransferase 2A
    XP_005620362.1
3930 aa
   KMT2A,  B.taurus
lysine (K)-specific methyltransferase 2A
    XP_002693122.2
3713 aa
   Kmt2a,  M.musculus
lysine (K)-specific methyltransferase 2A
    NP_001074518.1
3963 aa
   Kmt2a,  R.norvegicus
lysine (K)-specific methyltransferase 2A
    XP_006243039.1
3898 aa
   MLL,  G.gallus
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    XP_004948112.1
3881 aa
   kmt2a,  X.tropicalis
lysine (K)-specific methyltransferase 2A
    XP_002932944.2
3855 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukemia, myeloid/lymphoid or mixed-lineage.



Publications
Articles associated with genes and sequences of this homology group.

The MLL recombinome of acute leukemias in 2013.
Meyer C, et al. Leukemia 27, 2165-76 (2013).
In focus: MLL-rearranged leukemia.
de Boer J, et al. Leukemia 27, 1224-8 (2013).
Involvement of the MLL gene in adult T-lymphoblastic leukemia.
Türkmen S, et al. Genes Chromosomes Cancer 51, 1114-24 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHD (pfam00628)
  PHD-finger.
zf-CXXC (pfam02008)
  CXXC zinc finger domain.
PostSET (smart00508)
  Cysteine-rich motif following a subset of SET domains.
FYRN (pfam05964)
  F/Y-rich N-terminus.
zf-HC5HC2H (pfam13771)
  PHD-like zinc-binding domain.
zf-CXXC (pfam02008)
  CXXC zinc finger domain.
SOG2 (pfam10428)
  RAM signalling pathway protein.
Bromodomain (cl02556)
  Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
SET (cl02566)
  SET domain.
FYRC (cl02651)
  F/Y rich C-terminus.
FYRN (cl02650)
  This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00541.
PHD (cl17445)
  PHD-finger.
zf-HC5HC2H (cl17725)
  PHD-like zinc-binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mll1 includes H.sapiens MLL and R.norvegicus Mll1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 10 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Aves - birds (3 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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