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HomoloGene:86986. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NEDD4L,  H.sapiens
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
    NP_001138439.1
975 aa
   NEDD4L,  P.troglodytes
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
    XP_001140979.1
975 aa
   NEDD4L,  M.mulatta
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
    XP_001088661.2
1134 aa
   NEDD4L,  C.lupus
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
    XP_005615425.1
943 aa
   NEDD4L,  B.taurus
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
    XP_005224408.1
1255 aa
   Nedd4l,  M.musculus
neural precursor cell expressed, developmentally down-regulated gene 4-like
    NP_001107858.1
976 aa
   Nedd4l,  R.norvegicus
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
    NP_001008301.2
963 aa
   NEDD4L,  G.gallus
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
    XP_004949055.1
994 aa
   nedd4l,  X.tropicalis
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
    NP_001006727.1
970 aa
   nedd4l,  D.rerio
neural precursor cell expressed, developmentally down-regulated 4-like
    XP_005161145.1
995 aa
   Nedd4,  D.melanogaster
Nedd4
    NP_730284.2
931 aa
   AgaP_AGAP000787,  A.gambiae
AgaP_AGAP000787
    XP_311327.5
952 aa
   Y92H12A.2,  C.elegans
Y92H12A.2
    NP_490865.3
724 aa
   RSP5,  S.cerevisiae
RSP5
    NP_011051.3
809 aa
   KLLA0E13575g,  K.lactis
KLLA0E13575g
    XP_454562.1
819 aa
   AGOS_ADL055C,  E.gossypii
AGOS_ADL055C
    NP_984041.1
817 aa
   pub1,  S.pombe
pub1
    NP_594396.1
767 aa
   MGG_07255,  M.oryzae
MGG_07255
    XP_003715474.1
816 aa
   NCU03947,  N.crassa
NCU03947
    XP_957586.2
796 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Kito Y, et al. Int J Exp Pathol 95, 24-8 (2014).
Yeast ubiquitin ligase Rsp5 contains nuclear localization and export signals.
Cholbinski P, et al. Eur J Cell Biol 90, 834-43 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HECTc (smart00119)
  Domain Homologous to E6-AP Carboxyl Terminus with.
WW (cl00157)
  Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
C2 (cl14603)
  C2 domain.
Nup_retrotrp_bd (pfam10599)
  Retro-transposon transporting motif.
FAM53 (pfam15242)
  Family of FAM53.
HECTc (cl00077)
  HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
WW (cl00157)
  Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
C2 (cl14603)
  C2 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nedd4l includes H.sapiens NEDD4L and R.norvegicus Nedd4l.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (18 transcripts, 10 species)
Mammalia - mammals (16 transcripts, 13 species)
Aves - birds (5 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (7 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (3 transcripts, 3 species)
Liliopsida - monocots (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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