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HomoloGene:20086. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CFH,  H.sapiens
complement factor H
    NP_000177.2
1231 aa
   CFH,  P.troglodytes
complement factor H
    XP_001136531.1
1231 aa
   LOC717346,  M.mulatta
complement factor H-like
    XP_001111875.1
1235 aa
   LOC478952,  C.lupus
complement factor H-like
    XP_536110.2
1233 aa
   CFH,  B.taurus
complement factor H
    NP_001029108.1
1236 aa
   Cfh,  M.musculus
complement component factor h
    NP_034018.2
1252 aa
   Cfh,  R.norvegicus
complement factor H
    NP_569093.2
1235 aa
   CFH,  G.gallus
complement factor H
    XP_426613.3
1306 aa
   LOC100487763,  X.tropicalis
complement factor H-like
    XP_002932192.2
1323 aa
   cfh,  X.tropicalis
complement factor H
    NP_989218.1
781 aa
   LOC100492100,  X.tropicalis
complement factor H-like
    XP_002932215.2
571 aa
   LOC100496324,  X.tropicalis
complement factor H-like
    XP_002938373.2
498 aa
   f13b,  X.tropicalis
coagulation factor 13, B polypeptide
    XP_004919518.1
587 aa
   LOC100497957,  X.tropicalis
coagulation factor XIII B chain-like
    XP_002938382.2
401 aa
   LOC100497496,  X.tropicalis
coagulation factor XIII B chain-like
    XP_004919520.1
424 aa
   LOC100497803,  X.tropicalis
coagulation factor XIII B chain-like
    XP_002938381.1
422 aa
   LOC100491927,  X.tropicalis
complement factor H-like
    XP_002932214.2
722 aa
   LOC101731666,  X.tropicalis
complement factor H-related protein 2-like
    XP_004921059.1
126 aa
   cfh,  D.rerio
complement factor H
    NP_001186119.1
901 aa
   cfhl2,  D.rerio
complement factor H like 2
    NP_001007419.1
606 aa
   LOC100536017,  D.rerio
complement factor H-like
    XP_003201111.1
549 aa
   LOC100535929,  D.rerio
complement factor H-like
    XP_003201110.1
394 aa
   LOC100536554,  D.rerio
complement factor H-like
    XP_003201112.1
632 aa
   cfhl3,  D.rerio
complement factor H like 3
    NP_001186120.1
630 aa
   cfhl1,  D.rerio
complement factor H like 1
    NP_001032792.1
725 aa
   F36H2.3,  C.elegans
F36H2.3
    NP_001251038.1
1390 aa
   F36H2.5,  C.elegans
F36H2.5
    NP_001021461.2
449 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hemolytic-uremic syndrome.
Complement factor H deficiency.
Factor H and factor H-like 1.
Membranoproliferative glomerulonephritis with CFH deficiency.
Macular degeneration, age-related, 4.



Publications
Articles associated with genes and sequences of this homology group.

Immunology of age-related macular degeneration.
Ambati J, et al. Nat Rev Immunol 13, 438-51 (2013).
Functional anatomy of complement factor H.
Makou E, et al. Biochemistry 52, 3949-62 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Sushi_2 (pfam09014)
  Beta-2-glycoprotein-1 fifth domain.
Sushi (pfam00084)
  Sushi domain (SCR repeat).
PHA02927 (PHA02927)
  secreted complement-binding protein; Provisional.
CCP (cl00043)
  Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system.
CCP (cl00043)
  SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cfh includes H.sapiens CFH and R.norvegicus Cfh.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (5 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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