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HomoloGene:11156. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NOD2,  H.sapiens
nucleotide-binding oligomerization domain containing 2
    NP_071445.1
1040 aa
   NOD2,  P.troglodytes
nucleotide-binding oligomerization domain containing 2
    NP_001098710.1
1040 aa
   NOD2,  M.mulatta
nucleotide-binding oligomerization domain containing 2
    XP_001084287.1
1044 aa
   NOD2,  C.lupus
nucleotide-binding oligomerization domain-containing protein 2
    XP_005617627.1
1013 aa
   NOD2,  B.taurus
nucleotide-binding oligomerization domain containing 2
    NP_001002889.1
1013 aa
   Nod2,  M.musculus
nucleotide-binding oligomerization domain containing 2
    NP_665856.2
1013 aa
   Nod2,  R.norvegicus
nucleotide-binding oligomerization domain containing 2
    NP_001099642.1
932 aa
   nod2,  D.rerio
nucleotide-binding oligomerization domain containing 2
    XP_697924.3
980 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Sarcoidosis, early-onset.
Blau syndrome.
Crohn disease, susceptibility to.
Psoriatic arthritis, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammation.
Corridoni D, et al. Proc Natl Acad Sci U S A 110, 16999-7004 (2013).
NOD2-mediated innate immune signaling regulates the eicosanoids in atherosclerosis.
Liu HQ, et al. Arterioscler Thromb Vasc Biol 33, 2193-201 (2013).
NOD2/CARD15 mutations in Turkish patients with ankylosing spondylitis.
Kobak S, et al. Scand J Rheumatol 42, 249-50 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CARD_NOD2_2_CARD15 (cd08788)
  Caspase activation and recruitment domain of NOD2, repeat 2.
NACHT (pfam05729)
  NACHT domain.
LRR_RI (cd00116)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.
LRR_RI (cl15309)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nod2 includes H.sapiens NOD2 and R.norvegicus Nod2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)

 

 

 

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