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HomoloGene:1913. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   OPHN1,  H.sapiens
oligophrenin 1
    NP_002538.1
802 aa
   OPHN1,  P.troglodytes
oligophrenin 1
    NP_001009021.1
802 aa
   OPHN1,  C.lupus
oligophrenin 1
    XP_005641485.1
802 aa
   LOC525644,  B.taurus
oligophrenin-1-like
    XP_002700095.1
773 aa
   Ophn1,  M.musculus
oligophrenin 1
    NP_443208.1
802 aa
   Ophn1,  R.norvegicus
oligophrenin 1
    NP_001101318.1
802 aa
   OPHN1,  G.gallus
oligophrenin 1
    XP_420161.4
807 aa
   ophn1,  X.tropicalis
oligophrenin 1
    NP_001072480.1
792 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Mental retardation, X-linked, with cerebellar hypoplasia and distinctive facial appearance.



Publications
Articles associated with genes and sequences of this homology group.

Oligophrenin-1 (Ophn1) is expressed in mouse retinal vessels.
Sel S, et al. Gene Expr Patterns 12, 63-7 (2012).
Deletion of the OPHN1 gene detected by aCGH.
Madrigal I, et al. J Intellect Disabil Res 52, 190-4 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PH-like (cl00273)
  Pleckstrin homology-like domain.
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ophn1 includes H.sapiens OPHN1 and R.norvegicus Ophn1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (12 transcripts, 6 species)
Mammalia - mammals (9 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

 

 

 

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