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HomoloGene:68275. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PRPS1,  H.sapiens
phosphoribosyl pyrophosphate synthetase 1
    NP_002755.1
318 aa
   PRPS1,  P.troglodytes
phosphoribosyl pyrophosphate synthetase 1
    XP_001144504.1
318 aa
   PRPS1,  M.mulatta
phosphoribosyl pyrophosphate synthetase 1
    XP_001095604.1
318 aa
   PRPS1,  C.lupus
phosphoribosyl pyrophosphate synthetase 1
    XP_005641702.1
323 aa
   PRPS1,  B.taurus
phosphoribosyl pyrophosphate synthetase 1
    NP_001039654.1
318 aa
   Prps1,  M.musculus
phosphoribosyl pyrophosphate synthetase 1
    NP_067438.1
318 aa
   Prps1,  R.norvegicus
phosphoribosyl pyrophosphate synthetase 1
    NP_058939.1
318 aa
   PRPS1,  G.gallus
phosphoribosyl pyrophosphate synthetase 1
    XP_004940671.1
326 aa
   prps1b,  D.rerio
phosphoribosyl pyrophosphate synthetase 1B
    NP_001070036.1
318 aa
   CG6767,  D.melanogaster
CG6767
    NP_729528.2
388 aa
   AgaP_AGAP004890,  A.gambiae
AgaP_AGAP004890
    XP_001688552.1
438 aa
   AT2G35390,  A.thaliana
AT2G35390
    NP_850244.1
403 aa
   PRS2,  A.thaliana
PRS2
    NP_174516.1
400 aa
   AT2G44530,  A.thaliana
AT2G44530
    NP_181981.2
394 aa
   Os02g0127700,  O.sativa
Os02g0127700
    NP_001045763.1
396 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Gout, PRPS-related.
Phosphoribosylpyrophosphate synthetase superactivity.
Arts syndrome.
Charcot-Marie-Tooth disease, X-linked recessive, 5.



Publications
Articles associated with genes and sequences of this homology group.

PRPS1 mutations: four distinct syndromes and potential treatment.
de Brouwer AP, et al. Am J Hum Genet 86, 506-18 (2010).
Arts Syndrome
de Brouwer APM, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pribosyltran_N (pfam13793)
  N-terminal domain of ribose phosphate pyrophosphokinase.
Pribosyltran_N (pfam13793)
  N-terminal domain of ribose phosphate pyrophosphokinase.
PRTases_typeI (cl00309)
  Phosphoribosyl transferase (PRT)-type I domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prps1 includes H.sapiens PRPS1 and R.norvegicus Prps1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (23 transcripts, 15 species)
Actinopterygii - bony fishes (9 transcripts, 8 species)
Amphibia - amphibians (5 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 3 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (2 transcripts, 2 species)
Liliopsida - monocots (2 transcripts, 2 species)

Oomycetes
Pythiales - oomycetes (1 transcript, 1 species)

 

 

 

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