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HomoloGene:10411. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DLL4,  H.sapiens
delta-like 4 (Drosophila)
    NP_061947.1
685 aa
   DLL4,  P.troglodytes
delta-like 4 (Drosophila)
    XP_510318.2
685 aa
   DLL4,  M.mulatta
delta-like 4 (Drosophila)
    XP_002804774.1
724 aa
   DLL4,  C.lupus
delta-like 4 (Drosophila)
    XP_858084.1
685 aa
   DLL4,  B.taurus
delta-like 4 (Drosophila)
    NP_001069247.1
685 aa
   Dll4,  M.musculus
delta-like 4 (Drosophila)
    NP_062327.2
686 aa
   Dll4,  R.norvegicus
delta-like 4 (Drosophila)
    NP_001101230.1
685 aa
   DLL4,  G.gallus
delta-like 4 (Drosophila)
    XP_421132.2
798 aa
   dll4,  X.tropicalis
delta-like 4 (Drosophila)
    XP_002939596.2
673 aa
   dll4,  D.rerio
delta-like 4 (Drosophila)
    NP_001073304.1
683 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Clinical implications of DLL4 expression in gastric cancer.
Ishigami S, et al. J Exp Clin Cancer Res 32, 46 (2013).
Delta-like ligand 4-notch blockade and tumor radiation response.
Liu SK, et al. J Natl Cancer Inst 103, 1778-98 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MNNL (pfam07657)
  N terminus of Notch ligand.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
MNNL (pfam07657)
  N terminus of Notch ligand.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
DSL (cl19567)
  Delta serrate ligand.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dll4 includes H.sapiens DLL4 and R.norvegicus Dll4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 8 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (4 transcripts, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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