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HomoloGene:416. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ATRX,  H.sapiens
alpha thalassemia/mental retardation syndrome X-linked
    NP_000480.3
2492 aa
   ATRX,  P.troglodytes
alpha thalassemia/mental retardation syndrome X-linked
    NP_001009018.1
2492 aa
   ATRX,  M.mulatta
alpha thalassemia/mental retardation syndrome X-linked
    XP_001099874.1
2490 aa
   ATRX,  C.lupus
alpha thalassemia/mental retardation syndrome X-linked
    XP_538084.2
2489 aa
   ATRX,  B.taurus
alpha thalassemia/mental retardation syndrome X-linked
    XP_005228030.1
2478 aa
   Atrx,  M.musculus
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
    NP_033556.2
2476 aa
   Atrx,  R.norvegicus
alpha thalassemia/mental retardation syndrome X-linked
    XP_006257219.1
1415 aa
   ATRX,  G.gallus
alpha thalassemia/mental retardation syndrome X-linked
    XP_420305.3
2420 aa
   atrx,  X.tropicalis
alpha thalassemia/mental retardation syndrome X-linked
    XP_002931858.1
2268 aa
   atrx,  D.rerio
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
    NP_956947.2
2013 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Alpha-thalassemia myelodysplasia syndrome, somatic.
Sutherland-Haan syndrome-like.
Alpha-thalassemia/mental retardation syndrome.
Chudley-Lowry syndrome.
Juberg-Marsidi syndrome.
Mental retardation-hypotonic facies syndrome, X-linked.
Smith-Fineman-Myers syndrome.
Juberg-Marsidi syndrome.



Publications
Articles associated with genes and sequences of this homology group.

ATRX and the replication of structured DNA.
Clynes D & Gibbons RJ. Curr Opin Genet Dev 23, 289-94 (2013).
Chromatin structure and ATRX function in mouse oocytes.
De La Fuente R, et al. Results Probl Cell Differ 55, 45-68 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ADDz (cl17040)
  ADDz for ATRX, Dnmt3 and Dnmt3l PHD-like zinc finger domain.
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Atrx includes H.sapiens ATRX and R.norvegicus Atrx.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (30 transcripts, 13 species)
Actinopterygii - bony fishes (15 transcripts, 7 species)
Aves - birds (5 transcripts, 2 species)
Ascidiacea - tunicates (4 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 9 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Ascomycota
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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