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HomoloGene:3785. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   AKT1,  H.sapiens
v-akt murine thymoma viral oncogene homolog 1
    NP_001014431.1
480 aa
   AKT1,  P.troglodytes
v-akt murine thymoma viral oncogene homolog 1
    XP_001143158.2
426 aa
   AKT1,  M.mulatta
v-akt murine thymoma viral oncogene homolog 1
    XP_001085265.2
480 aa
   AKT1,  C.lupus
v-akt murine thymoma viral oncogene homolog 1
    XP_548000.3
480 aa
   AKT1,  B.taurus
v-akt murine thymoma viral oncogene homolog 1
    NP_776411.1
480 aa
   Akt1,  M.musculus
thymoma viral proto-oncogene 1
    NP_033782.1
480 aa
   Akt1,  R.norvegicus
v-akt murine thymoma viral oncogene homolog 1
    NP_150233.1
480 aa
   AKT1,  G.gallus
v-akt murine thymoma viral oncogene homolog 1
    NP_990386.1
480 aa
   akt1,  X.tropicalis
v-akt murine thymoma viral oncogene homolog 1
    XP_004917249.1
480 aa
   LOC100331515,  D.rerio
RAC-alpha serine/threonine-protein kinase-like
    XP_003200336.2
481 aa
   akt-1,  C.elegans
akt-1
    NP_001023646.1
546 aa
   akt-2,  C.elegans
akt-2
    NP_510357.3
528 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Schizophrenia, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Haploinsufficiency of akt1 prolongs the lifespan of mice.
Nojima A, et al. PLoS One 8, e69178 (2013).
Increased phosphorylation of AKT in high-risk gastric mucosa.
Sasaki T, et al. Anticancer Res 33, 3295-300 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Akt1 includes H.sapiens AKT1 and R.norvegicus Akt1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (11 transcripts, 5 species)
Mammalia - mammals (8 transcripts, 8 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (2 transcripts, 1 species)
Insecta - insects (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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