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HomoloGene:272. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RB1,  H.sapiens
retinoblastoma 1
    NP_000312.2
928 aa
   RB1,  P.troglodytes
retinoblastoma 1
    XP_509777.3
928 aa
   RB1,  C.lupus
retinoblastoma 1
    XP_534118.4
948 aa
   RB1,  B.taurus
retinoblastoma 1
    NP_001070375.1
928 aa
   Rb1,  M.musculus
retinoblastoma 1
    NP_033055.2
921 aa
   Rb1,  R.norvegicus
retinoblastoma 1
    NP_058741.1
920 aa
   RB1,  G.gallus
retinoblastoma 1
    NP_989750.1
921 aa
   rb1,  X.tropicalis
retinoblastoma 1
    XP_002935161.2
900 aa
   rb1,  D.rerio
retinoblastoma 1
    NP_001071248.1
903 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Bladder cancer.
Pinealoma with bilateral retinoblastoma.
Retinoblastoma.
Osteosarcoma.



Publications
Articles associated with genes and sequences of this homology group.

[Characteristics of RB1 gene mutations in Chinese patients with retinoblastoma].
He MY, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30, 509-12 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Rb_C (pfam08934)
  Rb C-terminal domain.
RB_A (pfam01858)
  Retinoblastoma-associated protein A domain.
RB_B (pfam01857)
  Retinoblastoma-associated protein B domain.
DUF3452 (pfam11934)
  Domain of unknown function (DUF3452).
CYCLIN (cl00050)
  Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
RB_B (pfam01857)
  Retinoblastoma-associated protein B domain.
RB_A (pfam01858)
  Retinoblastoma-associated protein A domain.
DUF3452 (pfam11934)
  Domain of unknown function (DUF3452).
CYCLIN (cl00050)
  Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rb1 includes H.sapiens RB1 and R.norvegicus Rb1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 10 species)
Actinopterygii - bony fishes (9 transcripts, 7 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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