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HomoloGene:39965. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SIGMAR1,  H.sapiens
sigma non-opioid intracellular receptor 1
    NP_005857.1
223 aa
   SIGMAR1,  P.troglodytes
sigma non-opioid intracellular receptor 1
    XP_520547.1
223 aa
   SIGMAR1,  M.mulatta
sigma non-opioid intracellular receptor 1
    XP_001096077.1
223 aa
   SIGMAR1,  C.lupus
sigma non-opioid intracellular receptor 1
    XP_852544.1
223 aa
   SIGMAR1,  B.taurus
sigma non-opioid intracellular receptor 1
    NP_001029827.1
223 aa
   Sigmar1,  M.musculus
sigma non-opioid intracellular receptor 1
    NP_035144.1
223 aa
   Sigmar1,  R.norvegicus
sigma non-opioid intracellular receptor 1
    NP_112258.1
223 aa
   SIGMAR1,  G.gallus
sigma non-opioid intracellular receptor 1
    NP_001257486.1
222 aa
   sigmar1,  D.rerio
sigma non-opioid intracellular receptor 1
    NP_957271.1
222 aa
   ERG2,  S.cerevisiae
ERG2
    NP_013929.1
222 aa
   KLLA0F06336g,  K.lactis
KLLA0F06336g
    XP_455367.1
223 aa
   AGOS_AFL181C,  E.gossypii
AGOS_AFL181C
    NP_985369.1
222 aa
   erg2,  S.pombe
erg2
    NP_593324.1
219 aa
   MGG_08624,  M.oryzae
MGG_08624
    XP_003711052.1
221 aa
   NCU04156,  N.crassa
NCU04156
    XP_961312.2
256 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Lack of sigma-1 receptor exacerbates ALS progression in mice.
Mavlyutov TA, et al. Neuroscience 240, 129-34 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ERG2_Sigma1R (pfam04622)
  ERG2 and Sigma1 receptor like protein.
ERG2_Sigma1R (pfam04622)
  ERG2 and Sigma1 receptor like protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sigmar1 includes H.sapiens SIGMAR1 and R.norvegicus Oprs1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Ascomycota
Sordariomycetes - ascomycetes (24 transcripts, 3 species)

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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