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HomoloGene:32240. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KDM1A,  H.sapiens
lysine (K)-specific demethylase 1A
    NP_001009999.1
876 aa
   KDM1A,  P.troglodytes
lysine (K)-specific demethylase 1A
    XP_513190.3
730 aa
   KDM1A,  M.mulatta
lysine (K)-specific demethylase 1A
    XP_001111525.2
876 aa
   KDM1A,  C.lupus
lysine (K)-specific demethylase 1A
    XP_005617878.1
873 aa
   KDM1A,  B.taurus
lysine (K)-specific demethylase 1A
    XP_002685762.1
877 aa
   Kdm1a,  M.musculus
lysine (K)-specific demethylase 1A
    NP_598633.2
853 aa
   Kdm1a,  R.norvegicus
lysine (K)-specific demethylase 1A
    NP_001123570.1
872 aa
   KDM1A,  G.gallus
lysine (K)-specific demethylase 1A
    XP_417719.4
781 aa
   kdm1a,  X.tropicalis
lysine (K)-specific demethylase 1A
    XP_002936640.1
833 aa
   kdm1a,  D.rerio
lysine (K)-specific demethylase 1a
    NP_001229924.1
833 aa
   Su(var)3-3,  D.melanogaster
Suppressor of variegation 3-3
    NP_649194.1
890 aa
   AgaP_AGAP011661,  A.gambiae
AgaP_AGAP011661
    XP_320852.4
826 aa
   spr-5,  C.elegans
spr-5
    NP_493366.1
770 aa
   lsd-1,  C.elegans
lsd-1
    NP_510000.2
737 aa
   MGG_09915,  M.oryzae
MGG_09915
    XP_003710013.1
1200 aa
   NCU09120,  N.crassa
NCU09120
    XP_958892.1
1374 aa
   LDL2,  A.thaliana
LDL2
    NP_187981.1
746 aa
   Os08g0143400,  O.sativa
Os08g0143400
    NP_001060976.1
763 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

KDM1 is a novel therapeutic target for the treatment of gliomas.
Sareddy GR, et al. Oncotarget 4, 18-28 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SWIRM (pfam04433)
  SWIRM domain.
NAD_binding_8 (pfam13450)
  NAD(P)-binding Rossmann-like domain.
SKA2 (cd12955)
  Spindle and kinetochore-associated protein 2.
DUF4201 (pfam13870)
  Domain of unknown function (DUF4201).
Amino_oxidase (pfam01593)
  Flavin containing amine oxidoreductase.
SWIRM (pfam04433)
  SWIRM domain.
Trigger_C (pfam05698)
  Bacterial trigger factor protein (TF) C-terminus.
HMG-box (cl00082)
  High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
Spectrin (cl02488)
  Spectrin repeat.
NAD_binding_8 (cl19134)
  NAD(P)-binding Rossmann-like domain.
Collagen (cl19732)
  Collagen triple helix repeat (20 copies).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kdm1a includes H.sapiens KDM1A.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 14 species)
Actinopterygii - bony fishes (18 transcripts, 8 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 4 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (3 transcripts, 1 species)
Hydrozoa - hydrozoans (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (8 transcripts, 6 species)
Liliopsida - monocots (7 transcripts, 6 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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