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HomoloGene:52329. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SYNE1,  H.sapiens
spectrin repeat containing, nuclear envelope 1
    NP_892006.3
8797 aa
   SYNE1,  P.troglodytes
spectrin repeat containing, nuclear envelope 1
    XP_518815.4
8696 aa
   SYNE1,  M.mulatta
spectrin repeat containing, nuclear envelope 1
    XP_001100631.2
8596 aa
   SYNE1,  C.lupus
spectrin repeat containing, nuclear envelope 1
    XP_005615580.1
8798 aa
   Syne1,  M.musculus
spectrin repeat containing, nuclear envelope 1
    NP_001073154.1
3010 aa
   Syne1,  R.norvegicus
spectrin repeat containing, nuclear envelope 1
    XP_006227911.1
5227 aa
   SYNE1,  G.gallus
spectrin repeat containing, nuclear envelope 1
    XP_419679.4
8789 aa
   syne1b,  D.rerio
spectrin repeat containing, nuclear envelope 1b
    XP_005158667.1
8792 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Spinocerebellar ataxia, autosomal recessive 8.



Publications
Articles associated with genes and sequences of this homology group.

SYNE1 mutations in autosomal recessive cerebellar ataxia.
Noreau A, et al. JAMA Neurol 70, 1296-31 (2013).
[Effect of nesprin-1 in the differentiation of mouse embryonic stem cells into cardiomyocytes].
Gao F, et al. Sichuan Da Xue Xue Bao Yi Xue Ban 43, 161-5 (2012).
Cytoskeletal interactions at the nuclear envelope mediated by nesprins.
Taranum S, et al. Int J Cell Biol 2012, 736524 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
KASH (pfam10541)
  Nuclear envelope localisation domain.
COG1511 (COG1511)
  Predicted membrane protein [Function unknown].
SMC_prok_B (TIGR02168)
  chromosome segregation protein SMC, common bacterial type.
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
SPEC (cl02488)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
KASH (pfam10541)
  Nuclear envelope localisation domain.
CH (cl00030)
  Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Syne1 includes H.sapiens SYNE1 and R.norvegicus Syne1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (52 transcripts, 13 species)
Actinopterygii - bony fishes (26 transcripts, 9 species)
Aves - birds (5 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 7 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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