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HomoloGene:21832. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NALCN,  H.sapiens
sodium leak channel, non-selective
    NP_443099.1
1738 aa
   NALCN,  P.troglodytes
sodium leak channel, non-selective
    XP_001149573.1
1738 aa
   NALCN,  C.lupus
sodium leak channel, non-selective
    XP_542654.4
1776 aa
   NALCN,  B.taurus
sodium leak channel, non-selective
    XP_002692026.1
1690 aa
   Nalcn,  M.musculus
sodium leak channel, non-selective
    NP_796367.3
1739 aa
   Nalcn,  R.norvegicus
sodium leak channel, non-selective
    NP_705894.1
1737 aa
   NALCN,  G.gallus
sodium leak channel, non-selective
    XP_416967.2
1738 aa
   nalcn,  X.tropicalis
sodium leak channel, non-selective
    XP_002937125.2
1744 aa
   nalcn,  D.rerio
sodium leak channel, non-selective
    NP_001017549.2
1742 aa
   na,  D.melanogaster
narrow abdomen
    NP_001096981.1
2232 aa
   AgaP_AGAP003921,  A.gambiae
AgaP_AGAP003921
    XP_318373.5
1842 aa
   unc-77,  C.elegans
unc-77
    NP_741413.2
1861 aa
   nca-2,  C.elegans
nca-2
    NP_498054.2
1785 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Lack of association of NALCN genetic variants with schizophrenia.
Souza RP, et al. Psychiatry Res 185, 450-2 (2011).
Use of Drosophila mutants to distinguish among volatile general anesthetics.
Campbell DB & Nash HA. Proc Natl Acad Sci U S A 91, 2135-9 (1994).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ion_trans (pfam00520)
  Ion transport protein.
Na_channel_gate (cd13433)
  Inactivation gate of the voltage-gated sodium channel alpha subunits.
Ion_trans (pfam00520)
  Ion transport protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nalcn includes H.sapiens NALCN and R.norvegicus Nalcn.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 8 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 3 species)
Arachnida - arachnids (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (5 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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