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HomoloGene:8053. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   FTO,  H.sapiens
fat mass and obesity associated
    NP_001073901.1
505 aa
   FTO,  P.troglodytes
fat mass and obesity associated
    XP_510968.2
505 aa
   FTO,  M.mulatta
fat mass and obesity associated
    XP_001092038.1
515 aa
   FTO,  C.lupus
fat mass and obesity associated
    XP_535301.4
549 aa
   FTO,  B.taurus
fat mass and obesity associated
    NP_001091611.1
505 aa
   Fto,  M.musculus
fat mass and obesity associated
    NP_036066.2
502 aa
   Fto,  R.norvegicus
fat mass and obesity associated
    NP_001034802.1
502 aa
   FTO,  G.gallus
fat mass and obesity associated
    NP_001172076.1
507 aa
   fto,  X.tropicalis
fat mass and obesity associated
    NP_001017273.1
498 aa
   fto,  D.rerio
fat mass and obesity associated
    XP_001345910.4
579 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Obesity, associated with.



Publications
Articles associated with genes and sequences of this homology group.

FTO genotype, vitamin D status, and weight gain during childhood.
Lourenço BH, et al. Diabetes 63, 808-14 (2014).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FTO_CTD (pfam12934)
  FTO C-terminal domain.
FTO_NTD (pfam12933)
  FTO catalytic domain.
FTO_NTD (pfam12933)
  FTO catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fto includes H.sapiens FTO and R.norvegicus Fto.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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