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HomoloGene:55440. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GCK,  H.sapiens
glucokinase (hexokinase 4)
    NP_000153.1
465 aa
   GCK,  P.troglodytes
glucokinase (hexokinase 4)
    XP_001143302.1
464 aa
   GCK,  M.mulatta
glucokinase (hexokinase 4)
    XP_001093035.2
465 aa
   GCK,  B.taurus
glucokinase (hexokinase 4)
    NP_001095772.1
465 aa
   Gck,  M.musculus
glucokinase
    NP_034422.2
465 aa
   Gck,  R.norvegicus
glucokinase
    NP_036697.1
465 aa
   GCK,  G.gallus
glucokinase (hexokinase 4)
    XP_427930.4
511 aa
   gck,  X.tropicalis
glucokinase (hexokinase 4)
    NP_001096321.1
458 aa
   gck,  D.rerio
glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
    NP_001038850.2
476 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes mellitus, gestational.
MODY, type II.
Diabetes mellitus, noninsulin-dependent, late onset.
Hyperinsulinemic hypoglycemia, familial, 3.
Diabetes mellitus, permanent neonatal.



Publications
Articles associated with genes and sequences of this homology group.

MODY2 caused by a novel mutation of GCK gene.
Pulst K, et al. J Pediatr Endocrinol Metab 25, 801-3 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NBD_sugar-kinase_HSP70_actin (cl17037)
  Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gck includes H.sapiens GCK and R.norvegicus Gck.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (13 transcripts, 9 species)
Mammalia - mammals (10 transcripts, 8 species)
Ascidiacea - tunicates (5 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (21 transcripts, 19 species)
Liliopsida - monocots (2 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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