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HomoloGene:4531. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PIN1,  H.sapiens
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
    NP_006212.1
163 aa
   PIN1,  P.troglodytes
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
    XP_001161990.1
163 aa
   PIN1,  C.lupus
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
    XP_542080.1
163 aa
   PIN1,  B.taurus
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
    NP_001029804.1
163 aa
   Pin1,  M.musculus
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
    NP_075860.1
165 aa
   Pin1,  R.norvegicus
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
    NP_001100171.1
165 aa
   PIN1,  G.gallus
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
    XP_003643613.2
79 aa
   pin1,  X.tropicalis
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
    NP_001008110.1
159 aa
   pin1,  D.rerio
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
    NP_957042.1
159 aa
   dod,  D.melanogaster
dodo
    NP_523428.1
166 aa
   AgaP_AGAP004321,  A.gambiae
AgaP_AGAP004321
    XP_313593.3
167 aa
   AgaP_AGAP013475,  A.gambiae
AgaP_AGAP013475
    XP_003436785.1
118 aa
   Y110A2AL.13,  C.elegans
Y110A2AL.13
    NP_494393.2
161 aa
   ESS1,  S.cerevisiae
ESS1
    NP_012551.2
170 aa
   KLLA0E16567g,  K.lactis
KLLA0E16567g
    XP_454696.1
162 aa
   AGOS_ACL120W,  E.gossypii
AGOS_ACL120W
    NP_983284.1
163 aa
   pin1,  S.pombe
pin1
    NP_587913.1
175 aa
   MGG_07389,  M.oryzae
MGG_07389
    XP_003711267.1
178 aa
   NCU08554,  N.crassa
NCU08554
    XP_963036.2
182 aa
   PIN1AT,  A.thaliana
PIN1AT
    NP_179395.1
119 aa
   Os04g0663800,  O.sativa
Os04g0663800
    NP_001054167.1
72 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Pin1 and nuclear receptors: a new language?
La Montagna R, et al. J Cell Physiol 228, 1799-801 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Rotamase_2 (cl08278)
  PPIC-type PPIASE domain.
WW (cl00157)
  Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
Rotamase_2 (cl08278)
  PPIC-type PPIASE domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pin1 includes H.sapiens PIN1 and R.norvegicus Pin1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (48 transcripts, 32 species)
Liliopsida - monocots (18 transcripts, 8 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Chordata
Mammalia - mammals (15 transcripts, 14 species)
Actinopterygii - bony fishes (10 transcripts, 10 species)
Ascidiacea - tunicates (4 transcripts, 1 species)
Aves - birds (3 transcripts, 1 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 13 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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