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HomoloGene:3946. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SFTPA1,  H.sapiens
surfactant protein A1
    NP_001087239.2
263 aa
   SFTPA1,  P.troglodytes
surfactant protein A1
    XP_001152394.2
263 aa
   SFTPA1,  M.mulatta
surfactant protein A1
    XP_002805703.1
263 aa
   LOC610540,  C.lupus
surfactant protein A1-like
    XP_003434532.2
277 aa
   SFTPA1,  B.taurus
surfactant protein A1
    NP_001071306.2
262 aa
   Sftpa1,  M.musculus
surfactant associated protein A1
    NP_075623.2
248 aa
   Sftpa1,  R.norvegicus
surfactant protein A1
    NP_001257574.1
258 aa
   LL,  G.gallus
lung lectin
    NP_001034255.1
198 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pulmonary fibrosis, idiopathic, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Surfactant protein A modulates induction of regulatory T cells via TGF-β.
Mukherjee S, et al. J Immunol 188, 4376-84 (2012).
Surfactant protein A is defective in abrogating inflammation in asthma.
Wang Y, et al. Am J Physiol Lung Cell Mol Physiol 301, L598-606 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CLECT (cl02432)
  C-type lectin (CTL)/C-type lectin-like (CTLD) domain.
Collagen (cl19732)
  Collagen triple helix repeat (20 copies).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sftpa1 includes H.sapiens SFTPA1B and R.norvegicus Sftpa1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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