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HomoloGene:12972. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PPP1R1B,  H.sapiens
protein phosphatase 1, regulatory (inhibitor) subunit 1B
    NP_115568.2
204 aa
   PPP1R1B,  P.troglodytes
protein phosphatase 1, regulatory (inhibitor) subunit 1B
    XP_001149814.2
203 aa
   PPP1R1B,  M.mulatta
protein phosphatase 1, regulatory (inhibitor) subunit 1B
    XP_001089386.2
204 aa
   PPP1R1B,  C.lupus
protein phosphatase 1, regulatory (inhibitor) subunit 1B
    XP_005624616.1
205 aa
   PPP1R1B,  B.taurus
protein phosphatase 1, regulatory (inhibitor) subunit 1B
    NP_777072.1
202 aa
   Ppp1r1b,  M.musculus
protein phosphatase 1, regulatory (inhibitor) subunit 1B
    NP_659077.1
194 aa
   Ppp1r1b,  R.norvegicus
protein phosphatase 1, regulatory (inhibitor) subunit 1B
    NP_612530.1
205 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Methylphenidate restores novel object recognition in DARPP-32 knockout mice.
Heyser CJ, et al. Behav Brain Res 253, 266-73 (2013).
Resistance to TRAIL is mediated by DARPP-32 in gastric cancer.
Belkhiri A, et al. Clin Cancer Res 18, 3889-900 (2012).
DARPP-32 is required for MAPK/ERK signaling in thyroid cells.
Chocarro-Calvo A, et al. Mol Endocrinol 26, 471-80 (2012).
Altered DARPP-32 expression in the superior temporal gyrus in schizophrenia.
Kunii Y, et al. Prog Neuropsychopharmacol Biol Psychiatry 35, 1139-43 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DARPP-32 (pfam05395)
  Protein phosphatase inhibitor 1/DARPP-32.
DARPP-32 (pfam05395)
  Protein phosphatase inhibitor 1/DARPP-32.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ppp1r1b includes H.sapiens PPP1R1B and R.norvegicus Ppp1r1b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Amniota - vertebrates (2 transcripts, 1 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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