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HomoloGene:635. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GAD1,  H.sapiens
glutamate decarboxylase 1 (brain, 67kDa)
    NP_000808.2
594 aa
   GAD1,  P.troglodytes
glutamate decarboxylase 1 (brain, 67kDa)
    NP_001029285.1
594 aa
   GAD1,  M.mulatta
glutamate decarboxylase 1 (brain, 67kDa)
    XP_001082995.1
594 aa
   GAD1,  C.lupus
glutamate decarboxylase 1 (brain, 67kDa)
    NP_001091012.1
594 aa
   GAD1,  B.taurus
glutamate decarboxylase 1 (brain, 67kDa)
    NP_001069224.1
594 aa
   Gad1,  M.musculus
glutamate decarboxylase 1
    NP_032103.2
593 aa
   Gad1,  R.norvegicus
glutamate decarboxylase 1
    NP_058703.1
593 aa
   GAD1,  G.gallus
glutamate decarboxylase 1 (brain, 67kDa)
    NP_990244.1
590 aa
   gad1,  X.tropicalis
glutamate decarboxylase 1 (brain, 67kDa)
    XP_004917767.1
590 aa
   Gad1,  D.melanogaster
Glutamic acid decarboxylase 1
    NP_728931.1
510 aa
   AgaP_AGAP005866,  A.gambiae
AgaP_AGAP005866
    XP_315894.2
512 aa
   unc-25,  C.elegans
unc-25
    NP_499689.1
508 aa
   MGG_03869,  M.oryzae
MGG_03869
    XP_003720021.1
515 aa
   NCU06112,  N.crassa
NCU06112
    XP_959974.1
545 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Cloned by cross-hybridization with feline GAD-encoding gene. The structural gene for glutamic acid decarboxylase. Cloned by cross-hybridization with feline GAD-encoding gene. Gad probes detect putative GAD-encoding 3.1-kb mRNA, from 4-8 h of embryogenesis to adulthood; a 2.6-kb RNA was also found, in embryos and pupae only; in situ hybridization detects the RNA(s) in widely, but not uniformly, distributed CNS cortical regions (of adult heads and larvae), with no detectable signals in non-neural tissues..

H.sapiens
Cerebral palsy, spastic, symmetric, autosomal recessive.



Publications
Articles associated with genes and sequences of this homology group.

Activity-dependent regulation of inhibition via GAD67.
Lau CG & Murthy VN. J Neurosci 32, 8521-31 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
AAT_I (cl18945)
  Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gad1 includes H.sapiens GAD1 and R.norvegicus Gad1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (15 transcripts, 7 species)
Mammalia - mammals (12 transcripts, 12 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 5 species)
Arachnida - arachnids (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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