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HomoloGene:32672. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PINK1,  H.sapiens
PTEN induced putative kinase 1
    NP_115785.1
581 aa
   PINK1,  P.troglodytes
PTEN induced putative kinase 1
    XP_001164912.2
581 aa
   LOC698013,  M.mulatta
serine/threonine-protein kinase PINK1, mitochondrial-like
    XP_001086306.1
581 aa
   PINK1,  M.mulatta
PTEN induced putative kinase 1
    XP_001096957.1
581 aa
   PINK1,  C.lupus
PTEN induced putative kinase 1
    XP_005617989.1
528 aa
   PINK1,  B.taurus
PTEN induced putative kinase 1
    NP_001093171.1
588 aa
   Pink1,  M.musculus
PTEN induced putative kinase 1
    NP_081156.2
580 aa
   Pink1,  R.norvegicus
PTEN induced putative kinase 1
    NP_001100164.1
257 aa
   PINK1,  G.gallus
PTEN induced putative kinase 1
    XP_423139.3
546 aa
   pink1,  D.rerio
PTEN induced putative kinase 1
    NP_001008628.1
574 aa
   pink-1,  C.elegans
pink-1
    NP_495017.1
641 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Parkinson disease (autosomal recessive) 6.
Parkinson disease 6, early onset.



Publications
Articles associated with genes and sequences of this homology group.

Function and characteristics of PINK1 in mitochondria.
Matsuda S, et al. Oxid Med Cell Longev 2013, 601587 (2013).
Increase of oxidative stress by a novel PINK1 mutation, P209A.
Chien WL, et al. Free Radic Biol Med 58, 160-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pink1 includes H.sapiens PINK1 and R.norvegicus Pink1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 14 species)
Actinopterygii - bony fishes (10 transcripts, 9 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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