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HomoloGene:10687. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PNPLA2,  H.sapiens
patatin-like phospholipase domain containing 2
    NP_065109.1
504 aa
   PNPLA2,  P.troglodytes
patatin-like phospholipase domain containing 2
    XP_003339482.2
591 aa
   LOC719842,  M.mulatta
patatin-like phospholipase domain-containing protein 2-like
    XP_001114582.2
167 aa
   PNPLA2,  C.lupus
patatin-like phospholipase domain containing 2
    XP_854164.2
459 aa
   PNPLA2,  B.taurus
patatin-like phospholipase domain containing 2
    NP_001039470.1
486 aa
   Pnpla2,  M.musculus
patatin-like phospholipase domain containing 2
    NP_001157161.1
486 aa
   LOC100911615,  R.norvegicus
patatin-like phospholipase domain-containing protein 2-like
    XP_003749062.1
478 aa
   Pnpla2,  R.norvegicus
patatin-like phospholipase domain containing 2
    NP_001101979.2
478 aa
   PNPLA2,  G.gallus
patatin-like phospholipase domain containing 2
    NP_001106762.1
483 aa
   pnpla2,  X.tropicalis
patatin-like phospholipase domain containing 2
    NP_001072695.1
491 aa
   C05D11.7,  C.elegans
C05D11.7
    NP_741196.1
621 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Neutral lipid storage disease with myopathy.



Publications
Articles associated with genes and sequences of this homology group.

Cardiac oxidative stress in a mouse model of neutral lipid storage disease.
Schrammel A, et al. Biochim Biophys Acta 1831, 1600-8 (2013).
Symptomatic lipid storage in carriers for the PNPLA2 gene.
Janssen MC, et al. Eur J Hum Genet 21, 807-15 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Patatin_and_cPLA2 (cl11396)
  Patatins and Phospholipases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pnpla2 includes H.sapiens PNPLA2 and R.norvegicus Pnpla2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (11 transcripts, 5 species)
Mammalia - mammals (9 transcripts, 9 species)
Aves - birds (6 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

 

 

 

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