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HomoloGene:16336. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PKHD1,  H.sapiens
polycystic kidney and hepatic disease 1 (autosomal recessive)
    NP_619639.3
4074 aa
   PKHD1,  P.troglodytes
polycystic kidney and hepatic disease 1 (autosomal recessive)
    XP_518534.2
4074 aa
   PKHD1,  M.mulatta
fibrocystin-like
    XP_002808437.1
3884 aa
   PKHD1,  C.lupus
polycystic kidney and hepatic disease 1 (autosomal recessive)
    XP_005627522.1
4074 aa
   LOC537895,  B.taurus
fibrocystin-like
    XP_002697357.2
4069 aa
   Pkhd1,  M.musculus
polycystic kidney and hepatic disease 1
    NP_694819.2
4059 aa
   PKHD1,  G.gallus
polycystic kidney and hepatic disease 1 (autosomal recessive)
    XP_420050.4
4034 aa
   pkhd1,  X.tropicalis
polycystic kidney and hepatic disease 1 (autosomal recessive)
    XP_002933649.2
3841 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Polycystic kidney and hepatic disease.



Publications
Articles associated with genes and sequences of this homology group.

Germline PKHD1 mutations are protective against colorectal cancer.
Ward CJ, et al. Hum Genet 129, 345-9 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TIG (pfam01833)
  IPT/TIG domain.
G8 (pfam10162)
  G8 domain.
Beta_helix (pfam13229)
  Right handed beta helix region.
PA14 (cl08459)
  PA14 domain.
IPT (cl15674)
  Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
G8 (pfam10162)
  G8 domain.
Beta_helix (pfam13229)
  Right handed beta helix region.
IPT (cl15674)
  Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pkhd1 includes H.sapiens PKHD1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 7 species)

 

 

 

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