Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:37910. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   BUB1,  H.sapiens
BUB1 mitotic checkpoint serine/threonine kinase
    NP_004327.1
1085 aa
   BUB1,  P.troglodytes
budding uninhibited by benzimidazoles 1 homolog (yeast)
    XP_001142040.1
1085 aa
   LOC696598,  M.mulatta
mitotic checkpoint serine/threonine-protein kinase BUB1-like
    XP_002808098.1
1085 aa
   BUB1,  C.lupus
BUB1 mitotic checkpoint serine/threonine kinase
    XP_005630473.1
1084 aa
   BUB1,  B.taurus
budding uninhibited by benzimidazoles 1 homolog (yeast)
    NP_001095481.1
1078 aa
   Bub1,  M.musculus
budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)
    NP_001106650.1
1059 aa
   Bub1,  R.norvegicus
BUB1 mitotic checkpoint serine/threonine kinase
    NP_001099977.1
1059 aa
   BUB1,  G.gallus
budding uninhibited by benzimidazoles 1 homolog (yeast)
    NP_001012888.1
1087 aa
   bub1,  X.tropicalis
BUB1 mitotic checkpoint serine/threonine kinase
    NP_001072830.1
1122 aa
   bub1,  D.rerio
BUB1 mitotic checkpoint serine/threonine kinase
    XP_002665685.2
1202 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Colorectal cancer with chromosomal instability.



Publications
Articles associated with genes and sequences of this homology group.

The kinetochore protein Bub1 participates in the DNA damage response.
Yang C, et al. DNA Repair (Amst) 11, 185-91 (2012).
Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice.
Leland S, et al. Proc Natl Acad Sci U S A 106, 12776-81 (2009).
BUB1 mediation of caspase-independent mitotic death determines cell fate.
Niikura Y, et al. J Cell Biol 178, 283-96 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Mad3_BUB1_I (cl07066)
  Mad3/BUB1 homology region 1.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Bub1 includes H.sapiens BUB1 and R.norvegicus Bub1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Aves - birds (3 transcripts, 2 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (10 transcripts, 9 species)
Liliopsida - monocots (2 transcripts, 2 species)
Coniferopsida - conifers (1 transcript, 1 species)

 

 

 

Write to the Help Desk