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HomoloGene:4117. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   SOS1,  H.sapiens
son of sevenless homolog 1 (Drosophila)
1333 aa
   SOS1,  P.troglodytes
son of sevenless homolog 1 (Drosophila)
1333 aa
   SOS1,  M.mulatta
son of sevenless homolog 1 (Drosophila)
1300 aa
   SOS1,  C.lupus
son of sevenless homolog 1 (Drosophila)
1414 aa
   SOS1,  B.taurus
son of sevenless homolog 1 (Drosophila)
1333 aa
   Sos1,  M.musculus
son of sevenless homolog 1 (Drosophila)
1319 aa
   Sos1,  R.norvegicus
Son of sevenless homolog 1 (Drosophila)
1319 aa
   SOS1,  G.gallus
son of sevenless homolog 1 (Drosophila)
1309 aa
   sos1,  X.tropicalis
son of sevenless homolog 1 (Drosophila)
1325 aa
   Sos,  D.melanogaster
Son of sevenless
1596 aa
   sos-1,  C.elegans
1493 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Recessive lethal or semi-lethal; heteroallelic or hemizygous escapers have small rough eyes; heterozygotes between two weak alleles viable with rough eyes.

Fibromatosis, gingival.
Noonan syndrome 4.

Articles associated with genes and sequences of this homology group.

A novel SOS1 mutation in Costello/CFC syndrome affects signaling in both RAS and PI3K pathways.
Tumurkhuu M, et al. J Recept Signal Transduct Res 33, 124-8 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Histone (pfam00125)
  Core histone H2A/H2B/H3/H4.
H4 (cl00074)
  Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string ...
RasGEF (cl02485)
  Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
REM (cl02520)
  Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
RhoGEF (cl02571)
  Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
PH-like (cl17171)
  Pleckstrin homology-like domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sos1 includes H.sapiens SOS1 and R.norvegicus Sos1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 8 species)
Actinopterygii - bony fishes (10 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)

Insecta - insects (4 transcripts, 4 species)
Arachnida - arachnids (1 transcript, 1 species)

Hirudinida - segmented worms (2 transcripts, 1 species)

Chromadorea - nematodes (1 transcript, 1 species)




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