Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:1793. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MDM2,  H.sapiens
MDM2 oncogene, E3 ubiquitin protein ligase
    NP_002383.2
497 aa
   MDM2,  P.troglodytes
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
    XP_001155208.1
497 aa
   MDM2,  M.mulatta
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
    XP_001117336.2
497 aa
   MDM2,  C.lupus
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
    NP_001003103.1
487 aa
   MDM2,  B.taurus
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
    NP_001092577.1
492 aa
   Mdm2,  M.musculus
transformed mouse 3T3 cell double minute 2
    NP_034916.1
489 aa
   Mdm2,  R.norvegicus
MDM2 oncogene, E3 ubiquitin protein ligase
    NP_001101569.1
458 aa
   MDM2,  G.gallus
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
    NP_001186313.1
483 aa
   mdm2,  X.tropicalis
MDM2 oncogene, E3 ubiquitin protein ligase
    NP_001231689.1
497 aa
   mdm2,  D.rerio
transformed 3T3 cell double minute 2 homolog (mouse)
    NP_571439.2
475 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Accelerated tumor formation, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Podocyte loss involves MDM2-driven mitotic catastrophe.
Mulay SR, et al. J Pathol 230, 322-35 (2013).
Association between MDM2 SNP309 T>G and risk of gastric cancer: a meta-analysis.
Tian X, et al. Asian Pac J Cancer Prev 14, 1925-9 (2013).
Ewing Sarcoma: influence of TP53 Arg72Pro and MDM2 T309G SNPs.
Thurow HS, et al. Mol Biol Rep 40, 4929-34 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SWIB (pfam02201)
  SWIB/MDM2 domain.
zf-RanBP (pfam00641)
  Zn-finger in Ran binding protein and others.
zf-C3HC4_2 (pfam13923)
  Zinc finger, C3HC4 type (RING finger).
zf-RanBP (cl02656)
  Zn-finger in Ran binding protein and others.
zf-C3HC4_3 (pfam13920)
  Zinc finger, C3HC4 type (RING finger).
SWIB (cl02489)
  SWIB/MDM2 domain.
zf-RanBP (cl02656)
  Zn-finger in Ran binding protein and others.
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mdm2 includes H.sapiens MDM2 and R.norvegicus Mdm2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 13 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

Write to the Help Desk