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HomoloGene:20581. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PIK3C2A,  H.sapiens
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
    NP_002636.2
1686 aa
   PIK3C2A,  P.troglodytes
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
    XP_001172532.1
1686 aa
   LOC697202,  M.mulatta
phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha-like
    XP_002808122.1
1666 aa
   PIK3C2A,  C.lupus
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
    XP_005633773.1
1688 aa
   PIK3C2A,  B.taurus
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
    XP_002693140.2
1664 aa
   Pik3c2a,  M.musculus
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
    NP_035213.2
1686 aa
   Pik3c2a,  R.norvegicus
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
    NP_001101970.1
1687 aa
   PIK3C2A,  G.gallus
phosphoinositide-3-kinase, class 2, alpha polypeptide
    XP_421003.2
1700 aa
   pik3c2a,  X.tropicalis
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
    NP_001128289.1
1690 aa
   pik3c2a,  D.rerio
phosphoinositide-3-kinase, class 2, alpha polypeptide
    XP_005159363.1
1691 aa
   Pi3K68D,  D.melanogaster
Phosphotidylinositol 3 kinase 68D
    NP_524028.2
1876 aa
   AgaP_AGAP011036,  A.gambiae
AgaP_AGAP011036
    XP_001237042.2
1954 aa
   piki-1,  C.elegans
piki-1
    NP_510529.1
1607 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Role of class II phosphoinositide 3-kinase in cell signalling.
Falasca M & Maffucci T. Biochem Soc Trans 35, 211-4 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PI3K_rbd (pfam00794)
  PI3-kinase family, ras-binding domain.
PI3K_rbd (cl02484)
  PI3-kinase family, ras-binding domain.
ETS_PEA3_N (pfam04621)
  PEA3 subfamily ETS-domain transcription factor N terminal domain.
DamX (COG3266)
  Uncharacterized protein conserved in bacteria [Function unknown].
PI3Kc_like (cl00119)
  Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...
PI3Ka (cl00271)
  Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
C2 (cl14603)
  C2 domain.
PI3Kc_like (cl00119)
  Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...
ALAD_PBGS (cl00338)
  Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...
PI3K_rbd (cl02484)
  PI3-kinase family, ras-binding domain.
PX_domain (cl02563)
  The Phox Homology domain, a phosphoinositide binding module.
C2 (cl14603)
  C2 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pik3c2a includes H.sapiens PIK3C2A and R.norvegicus Pik3c2a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 10 species)
Actinopterygii - bony fishes (10 transcripts, 6 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

 

 

 

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