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HomoloGene:128570. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KCNA3,  H.sapiens
potassium voltage-gated channel, shaker-related subfamily, member 3
    NP_002223.3
575 aa
   KCNA3,  P.troglodytes
potassium voltage-gated channel, shaker-related subfamily, member 3
    XP_524797.1
575 aa
   KCNA3,  M.mulatta
potassium voltage-gated channel, shaker-related subfamily, member 3
    XP_001101652.1
575 aa
   KCNA3,  C.lupus
potassium voltage-gated channel, shaker-related subfamily, member 3
    XP_003434878.2
432 aa
   KCNA3,  B.taurus
potassium voltage-gated channel, shaker-related subfamily, member 3
    XP_005204275.1
576 aa
   Kcna3,  M.musculus
potassium voltage-gated channel, shaker-related subfamily, member 3
    NP_032444.2
528 aa
   Kcna3,  R.norvegicus
potassium voltage-gated channel, shaker-related subfamily, member 3
    NP_062143.3
525 aa
   KCNA3,  G.gallus
potassium voltage-gated channel, shaker-related subfamily, member 3
    NP_001025549.1
580 aa
   kcna1,  X.tropicalis
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
    XP_004910792.1
526 aa
   LOC100150068,  D.rerio
potassium voltage-gated channel subfamily A member 3-like
    XP_005172172.1
515 aa
   LOC100330283,  D.rerio
potassium voltage-gated channel subfamily A member 3-like
    XP_005174156.1
515 aa
   Sh,  D.melanogaster
Shaker
    NP_523393.3
616 aa
   AgaP_AGAP000254,  A.gambiae
AgaP_AGAP000254
    XP_310869.5
612 aa
   shk-1,  C.elegans
shk-1
    NP_496104.2
481 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Under moderate ether anesthesia, legs shake abnormally, antennae twitch, abdomen pulsates; wings scissor in some alleles; very little effect in deeply etherized flies; unetherized mutants twitch and shudder occasionally; severed legs shake (Kaplan and Trout, 1969; Trout and Kaplan, 1973; Tanouye, Ferrus and Fujita, 1981; Ganetzky and Wu, 1982a; Tanouye and Ferrus, 1985). Structural gene for several types of potassium channel (Iverson et al., 1988; Timpe et al. Jan, 1988). Abnormal action potential repolarization of adult giant fiber; repetitive firing of action potentials in larval nerves; prolonged transmitter release at larval neuromuscular junction (Jan, Jan and Dennis, 1977; Tanouye, Ferrus and Fujita, 1981; Ganetzky and Wu, 1982b; Tanouye and Ferrus, 1985). (See FlyBase for complete description.)



Publications
Articles associated with genes and sequences of this homology group.

Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance.
Upadhyay SK, et al. Proc Natl Acad Sci U S A 110, E2239-48 (2013).
Odor enrichment sculpts the abundance of olfactory bulb mitral cells.
Johnson MC, et al. Neurosci Lett 541, 173-8 (2013).
Benidipine persistently inhibits delayed rectifier K(+)-channel currents in murine thymocytes.
Kazama I, et al. Immunopharmacol Immunotoxicol 35, 28-33 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
K_tetra (pfam02214)
  K+ channel tetramerisation domain.
Ion_trans (pfam00520)
  Ion transport protein.
BTB (cl02518)
  BTB/POZ domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kcna3 includes H.sapiens KCNA3 and R.norvegicus Kcna3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

 

 

 

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