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HomoloGene:913. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ALDH7A1,  H.sapiens
aldehyde dehydrogenase 7 family, member A1
    NP_001173.2
539 aa
   ALDH7A1,  P.troglodytes
aldehyde dehydrogenase 7 family, member A1
    XP_001157473.2
566 aa
   ALDH7A1,  M.mulatta
aldehyde dehydrogenase 7 family, member A1
    XP_001095681.2
566 aa
   ALDH7A1,  C.lupus
aldehyde dehydrogenase 7 family, member A1
    XP_538607.3
566 aa
   ALDH7A1,  B.taurus
aldehyde dehydrogenase 7 family, member A1
    NP_001039434.2
539 aa
   Aldh7a1,  M.musculus
aldehyde dehydrogenase family 7, member A1
    NP_613066.2
539 aa
   Aldh7a1,  R.norvegicus
aldehyde dehydrogenase 7 family, member A1
    NP_001258034.1
539 aa
   ALDH7A1,  G.gallus
aldehyde dehydrogenase 7 family, member A1
    XP_424422.2
536 aa
   aldh7a1,  X.tropicalis
aldehyde dehydrogenase 7 family, member A1
    NP_001016377.1
511 aa
   aldh7a1,  D.rerio
aldehyde dehydrogenase 7 family, member A1
    NP_997889.1
511 aa
   CG9629,  D.melanogaster
CG9629
    NP_649099.1
540 aa
   AgaP_AGAP000881,  A.gambiae
AgaP_AGAP000881
    XP_316857.3
540 aa
   alh-9,  C.elegans
alh-9
    NP_498263.2
531 aa
   ALDH7B4,  A.thaliana
ALDH7B4
    NP_175812.1
508 aa
   Os09g0440300,  O.sativa
Os09g0440300
    NP_001063281.1
509 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Epilepsy, pyridoxine-dependent.



Publications
Articles associated with genes and sequences of this homology group.

Normal plasma pipecolic acid level in pyridoxine dependent epilepsy due to ALDH7A1 mutations.
Mercimek-Mahmutoglu S, et al. Mol Genet Metab 110, 197 (2013).
Atypical pyridoxine-dependent epilepsy due to a pseudoexon in ALDH7A1.
Milh M, et al. Mol Genet Metab 105, 684-6 (2012).
Human antiquitin: structural and functional studies.
Chan CL, et al. Chem Biol Interact 191, 165-70 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ALDH-SF (cl11961)
  NAD(P)+-dependent aldehyde dehydrogenase superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aldh7a1 includes H.sapiens ALDH7A1 and R.norvegicus Aldh7a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 14 species)
Actinopterygii - bony fishes (14 transcripts, 11 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 9 species)
Arachnida - arachnids (2 transcripts, 2 species)
Malacostraca - crustaceans (2 transcripts, 1 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Porifera
Demospongiae - sponges (3 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (42 transcripts, 34 species)
Liliopsida - monocots (13 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (3 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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