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HomoloGene:55857. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ACTN4,  H.sapiens
actinin, alpha 4
    NP_004915.2
911 aa
   ACTN4,  P.troglodytes
actinin, alpha 4
    XP_003954421.1
911 aa
   ACTN4,  M.mulatta
actinin, alpha 4
    XP_001083825.1
911 aa
   ACTN4,  C.lupus
actinin, alpha 4
    XP_541640.2
933 aa
   ACTN4,  B.taurus
actinin, alpha 4
    NP_001091521.1
911 aa
   Actn4,  M.musculus
actinin alpha 4
    NP_068695.1
912 aa
   Actn4,  R.norvegicus
actinin alpha 4
    NP_113863.2
911 aa
   ACTN4,  G.gallus
actinin, alpha 4
    NP_990457.1
904 aa
   actn4,  X.tropicalis
actinin, alpha 4
    NP_001006810.1
904 aa
   actn4,  D.rerio
actinin, alpha 4
    NP_955880.1
901 aa
   ain1,  S.pombe
ain1
    NP_594295.1
621 aa
   MGG_06475,  M.oryzae
MGG_06475
    XP_003717088.1
788 aa
   NCU06429,  N.crassa
NCU06429
    XP_957320.1
1027 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Glomerulosclerosis, focal segmental, 1.



Publications
Articles associated with genes and sequences of this homology group.

Alpha-actinin 4 and tumorigenesis of breast cancer.
Hsu KS & Kao HY. Vitam Horm 93, 323-51 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
efhand_Ca_insen (pfam08726)
  Ca2+ insensitive EF hand.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
EFhand_Ca_insen (pfam08726)
  Ca2+ insensitive EF hand.
CH (cl00030)
  Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
Spectrin (cl02488)
  Spectrin repeat.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Actn4 includes H.sapiens ACTN4 and R.norvegicus Actn4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 11 species)
Actinopterygii - bony fishes (15 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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