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HomoloGene:47927. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   APOA4,  H.sapiens
apolipoprotein A-IV
    NP_000473.2
396 aa
   APOA4,  P.troglodytes
apolipoprotein A-IV
    XP_522192.2
396 aa
   APOA4,  M.mulatta
apolipoprotein A-IV
    XP_001090730.2
440 aa
   APOA4,  C.lupus
apolipoprotein A-IV
    XP_546510.3
384 aa
   APOA4,  B.taurus
apolipoprotein A-IV
    NP_001032557.1
380 aa
   Apoa4,  M.musculus
apolipoprotein A-IV
    NP_031494.2
395 aa
   Apoa4,  R.norvegicus
apolipoprotein A-IV
    NP_036869.1
391 aa
   APOA4,  G.gallus
apolipoprotein A-IV
    NP_990269.1
366 aa
   apoa4,  X.tropicalis
apolipoprotein A4
    NP_001008099.1
368 aa
   zgc:194131,  D.rerio
zgc:194131
    NP_001122230.1
255 aa
   zgc:112992,  D.rerio
zgc:112992
    NP_001017909.1
234 aa
   apoa4,  D.rerio
apolipoprotein A-IV
    NP_001073330.1
255 aa
   si:dkey-7f3.15,  D.rerio
si:dkey-7f3.15
    XP_001338037.1
255 aa
   LOC100005908,  D.rerio
apolipoprotein A-IV-like
    XP_001344822.2
169 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Is apolipoprotein A-IV rate limiting in the intestinal transport and absorption of triglyceride?
Kohan AB, et al. Am J Physiol Gastrointest Liver Physiol 304, G1128-35 (2013).
Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion.
Wang F, et al. Proc Natl Acad Sci U S A 109, 9641-6 (2012).
Effect of peripheral administration of cholecystokinin on food intake in apolipoprotein AIV knockout mice.
Yoshimichi G, et al. Am J Physiol Gastrointest Liver Physiol 302, G1336-42 (2012).
Apolipoprotein A-IV regulates chylomicron metabolism-mechanism and function.
Kohan AB, et al. Am J Physiol Gastrointest Liver Physiol 302, G628-36 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Apolipoprotein (pfam01442)
  Apolipoprotein A1/A4/E domain.
GluZincin (cl14813)
  Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins).
Apolipoprotein (pfam01442)
  Apolipoprotein A1/A4/E domain.
TroA-like (cl00262)
  Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Apoa4 includes H.sapiens APOA4 and R.norvegicus Apoa4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (22 transcripts, 10 species)
Mammalia - mammals (12 transcripts, 11 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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