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HomoloGene:3820. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CTLA4,  H.sapiens
cytotoxic T-lymphocyte-associated protein 4
    NP_005205.2
223 aa
   CTLA4,  P.troglodytes
cytotoxic T-lymphocyte-associated protein 4
    XP_526000.1
223 aa
   CTLA4,  M.mulatta
cytotoxic T-lymphocyte-associated protein 4
    NP_001038204.1
223 aa
   CTLA4,  C.lupus
cytotoxic T-lymphocyte-associated protein 4
    NP_001003106.1
223 aa
   CTLA4,  B.taurus
cytotoxic T-lymphocyte-associated protein 4
    NP_776722.1
221 aa
   Ctla4,  M.musculus
cytotoxic T-lymphocyte-associated protein 4
    NP_033973.2
223 aa
   Ctla4,  R.norvegicus
cytotoxic T-lymphocyte-associated protein 4
    NP_113862.1
223 aa
   CTLA4,  G.gallus
cytotoxic T-lymphocyte-associated protein 4
    NP_001035180.1
205 aa
   ctla4,  X.tropicalis
cytotoxic T-lymphocyte-associated protein 4
    XP_002936576.1
209 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hypothyroidism, autoimmune.
Graves disease, susceptibility to.
Diabetes mellitus, insulin-dependent, 12.
Diabetes mellitus, insulin-dependent, susceptibility to.
Celiac disease, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

CTLA-4 and autoimmunity: new insights into the dual regulator of tolerance.
Romo-Tena J, et al. Autoimmun Rev 12, 1171-6 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ig (cl11960)
  Immunoglobulin domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ctla4 includes H.sapiens CTLA4 and R.norvegicus Ctla4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 11 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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