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HomoloGene:8422. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   POU5F1,  H.sapiens
POU class 5 homeobox 1
    NP_002692.2
360 aa
   POU5F1,  P.troglodytes
POU class 5 homeobox 1
    NP_001238970.1
360 aa
   POU5F1,  M.mulatta
POU class 5 homeobox 1
    NP_001108427.1
360 aa
   POU5F1,  C.lupus
POU class 5 homeobox 1
    XP_538830.1
360 aa
   POU5F1,  B.taurus
POU class 5 homeobox 1
    NP_777005.1
360 aa
   Pou5f1,  M.musculus
POU domain, class 5, transcription factor 1
    NP_038661.2
352 aa
   Pou5f1,  R.norvegicus
POU class 5 homeobox 1
    NP_001009178.1
352 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Establishment of totipotency does not depend on Oct4A.
Wu G, et al. Nat Cell Biol 15, 1089-97 (2013).
Prognostication of OCT4 isoform expression in prostate cancer.
de Resende MF, et al. Tumour Biol 34, 2665-73 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Pou (cl02582)
  Pou domain - N-terminal to homeobox domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pou5f1 includes H.sapiens POU5F1 and R.norvegicus Pou5f1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 12 species)
Amphibia - amphibians (2 transcripts, 2 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

 

 

 

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