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HomoloGene:37558. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   EPHX2,  H.sapiens
epoxide hydrolase 2, cytoplasmic
    NP_001970.2
555 aa
   EPHX2,  P.troglodytes
epoxide hydrolase 2, cytoplasmic
    XP_001163779.1
555 aa
   EPHX2,  M.mulatta
epoxide hydrolase 2, cytoplasmic
    XP_001109474.2
502 aa
   EPHX2,  C.lupus
epoxide hydrolase 2, cytoplasmic
    XP_005635733.1
556 aa
   EPHX2,  B.taurus
epoxide hydrolase 2, cytoplasmic
    NP_001069002.1
555 aa
   Ephx2,  M.musculus
epoxide hydrolase 2, cytoplasmic
    NP_031966.2
554 aa
   Ephx2,  R.norvegicus
epoxide hydrolase 2, cytoplasmic
    NP_075225.1
554 aa
   EPHX2,  G.gallus
epoxide hydrolase 2, cytoplasmic
    NP_001028817.1
562 aa
   ephx2,  X.tropicalis
epoxide hydrolase 2, cytoplasmic
    NP_001006912.1
560 aa
   ephx2,  D.rerio
epoxide hydrolase 2, cytoplasmic
    NP_001008642.1
557 aa
   MGG_05175,  M.oryzae
MGG_05175
    XP_003712714.1
366 aa
   AT3G51000,  A.thaliana
AT3G51000
    NP_190669.1
323 aa
   Os12g0636400,  O.sativa
Os12g0636400
    NP_001067364.1
320 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hypercholesterolemia, familial, due to LDLR defect, modifier of.



Publications
Articles associated with genes and sequences of this homology group.

Epoxyeicosanoids promote organ and tissue regeneration.
Panigrahy D, et al. Proc Natl Acad Sci U S A 110, 13528-33 (2013).
Soluble epoxide hydrolase dimerization is required for hydrolase activity.
Nelson JW, et al. J Biol Chem 288, 7697-703 (2013).
Epoxyeicosatrienoic acid pathway in human health and diseases.
Bellien J & Joannides R. J Cardiovasc Pharmacol 61, 188-96 (2013).
Altered behavioral phenotypes in soluble epoxide hydrolase knockout mice: effects of traumatic brain injury.
Strauss KI, et al. Prostaglandins Other Lipid Mediat 104-105, 18-24 (2013).
Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats.
Guglielmino K, et al. Am J Physiol Heart Circ Physiol 303, H853-62 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HAD_like (cd01427)
  Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
PRK09456 (PRK09456)
  ?-D-glucose-1-phosphatase; Provisional.
DREG-2 (TIGR02252)
  REG-2-like, HAD superfamily (subfamily IA) hydrolase.
Abhydrolase_1 (pfam00561)
  alpha/beta hydrolase fold.
Esterase_lipase (cl12031)
  Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
Hydrolase_4 (pfam12146)
  Putative lysophospholipase.
Abhydrolase_6 (pfam12697)
  Alpha/beta hydrolase family.
MhpC (COG0596)
  Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].
Abhydrolase_1 (pfam00561)
  alpha/beta hydrolase fold.
Hydrolase_4 (cl19140)
  Putative lysophospholipase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ephx2 includes H.sapiens EPHX2 and R.norvegicus Ephx2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (24 transcripts, 18 species)
Liliopsida - monocots (11 transcripts, 7 species)
Coniferopsida - conifers (2 transcripts, 2 species)

Chordata
Mammalia - mammals (15 transcripts, 13 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Ascidiacea - tunicates (3 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Eurotiomycetes - ascomycetes (2 transcripts, 1 species)
Sordariomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (3 transcripts, 1 species)

 

 

 

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