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HomoloGene:592. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CHRNA4,  H.sapiens
cholinergic receptor, nicotinic, alpha 4 (neuronal)
    NP_000735.1
627 aa
   CHRNA4,  P.troglodytes
cholinergic receptor, nicotinic, alpha 4 (neuronal)
    NP_001029286.1
627 aa
   CHRNA4,  M.mulatta
cholinergic receptor, nicotinic, alpha 4 (neuronal)
    XP_001114265.2
697 aa
   CHRNA4,  C.lupus
cholinergic receptor, nicotinic, alpha 4 (neuronal)
    XP_543097.3
618 aa
   CHRNA4,  B.taurus
cholinergic receptor, nicotinic, alpha 4
    NP_001179829.1
614 aa
   Chrna4,  M.musculus
cholinergic receptor, nicotinic, alpha polypeptide 4
    NP_056545.3
629 aa
   Chrna4,  R.norvegicus
cholinergic receptor, nicotinic, alpha 4 (neuronal)
    NP_077330.1
630 aa
   CHRNA4,  G.gallus
cholinergic receptor, nicotinic, alpha 4
    NP_990145.1
622 aa
   chrna4,  X.tropicalis
cholinergic receptor, nicotinic, alpha 4 (neuronal)
    NP_001107315.1
734 aa
   chrna4b,  D.rerio
cholinergic receptor, nicotinic, alpha 4b
    NP_001041528.1
627 aa
   LOC563696,  D.rerio
neuronal acetylcholine receptor subunit alpha-4-like
    XP_692148.2
627 aa
   nAcRbeta-64B,  D.melanogaster
nicotinic Acetylcholine Receptor beta 64B
    NP_523927.2
521 aa
   AgaP_AGAP000966,  A.gambiae
AgaP_AGAP000966
    XP_309158.3
519 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Nicotine addiction, susceptibility to.
Epilepsy, nocturnal frontal lobe, 1.



Publications
Articles associated with genes and sequences of this homology group.

Nicotinic acetylcholine receptors are sensors for ethanol in lung fibroblasts.
Ritzenthaler JD, et al. Alcohol Clin Exp Res 37, 914-23 (2013).
Nominal association with CHRNA4 variants and nicotine dependence.
Kamens HM, et al. Genes Brain Behav 12, 297-304 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RecQ5 (pfam06959)
  RecQ helicase protein-like 5 (RecQ5).
Neur_chan_memb (pfam02932)
  Neurotransmitter-gated ion-channel transmembrane region.
Neur_chan_LBD (pfam02931)
  Neurotransmitter-gated ion-channel ligand binding domain.
AF-4 (pfam05110)
  AF-4 proto-oncoprotein.
Neur_chan_memb (pfam02932)
  Neurotransmitter-gated ion-channel transmembrane region.
Neur_chan_LBD (pfam02931)
  Neurotransmitter-gated ion-channel ligand binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Chrna4 includes H.sapiens CHRNA4 and R.norvegicus Chrna4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 8 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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