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HomoloGene:14618. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   OPA1,  H.sapiens
optic atrophy 1 (autosomal dominant)
    NP_570849.2
997 aa
   OPA1,  P.troglodytes
optic atrophy 1 (autosomal dominant)
    XP_003310225.1
997 aa
   OPA1,  M.mulatta
optic atrophy 1 (autosomal dominant)
    XP_001087037.2
997 aa
   LOC477129,  C.lupus
dynamin-like 120 kDa protein, mitochondrial-like
    XP_005634679.1
1015 aa
   OPA1,  B.taurus
optic atrophy 1 (autosomal dominant)
    NP_001179890.1
997 aa
   Opa1,  M.musculus
optic atrophy 1
    NP_001186106.1
978 aa
   Opa1,  R.norvegicus
optic atrophy 1
    NP_598269.3
960 aa
   OPA1,  G.gallus
optic atrophy 1 (autosomal dominant)
    NP_001034398.1
977 aa
   opa1,  X.tropicalis
optic atrophy 1 (autosomal dominant)
    NP_001120510.1
761 aa
   opa1,  D.rerio
optic atrophy 1 (human)
    NP_001007299.1
966 aa
   LOC100307079,  D.rerio
optic atrophy 1-like
    XP_005166050.1
982 aa
   opa1-like,  D.melanogaster
optic atrophy 1-like
    NP_725369.1
972 aa
   AgaP_AGAP011286,  A.gambiae
AgaP_AGAP011286
    XP_309360.3
879 aa
   eat-3,  C.elegans
eat-3
    NP_495986.3
964 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Optic atrophy and deafness.
Optic atrophy 1.
Glaucoma, normal tension, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Dominant optic atrophy: novel OPA1 mutations and revised prevalence estimates.
Yu-Wai-Man P & Chinnery PF. Ophthalmology 120, 1712-1712.e1 (2013).
OPA1 loss of function affects in vitro neuronal maturation.
Bertholet AM, et al. Brain 136, 1518-33 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Opa1 includes H.sapiens OPA1 and R.norvegicus Opa1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 13 species)
Actinopterygii - bony fishes (14 transcripts, 7 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

 

 

 

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