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HomoloGene:55430. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CDKN2A,  H.sapiens
cyclin-dependent kinase inhibitor 2A
    NP_000068.1
156 aa
   CDKN2A,  P.troglodytes
cyclin-dependent kinase inhibitor 2A
    NP_001139762.1
156 aa
   LOC709988,  M.mulatta
cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3-like
    XP_001098554.1
308 aa
   CDKN2A,  C.lupus
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
    XP_003431646.2
108 aa
   CDKN2A,  B.taurus
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
    XP_002689593.3
160 aa
   Cdkn2a,  M.musculus
cyclin-dependent kinase inhibitor 2A
    NP_001035744.1
168 aa
   Cdkn2a,  R.norvegicus
cyclin-dependent kinase inhibitor 2A
    NP_113738.1
159 aa
   cdkn2b,  X.tropicalis
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
    NP_001006920.1
125 aa
   LOC100329528,  D.rerio
cyclin-dependent kinase inhibitor 2A-like
    XP_002660514.1
125 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Li Fraumeni syndrome.
Melanoma, cutaneous malignant, 2.
Melanoma and neural system tumor syndrome.
Orolaryngeal cancer, multiple.
Pancreatic cancer/melanoma syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines.
McLaughlin-Drubin ME, et al. Proc Natl Acad Sci U S A 110, 16175-80 (2013).
Immunohistochemical expression of p16 in desmoplastic melanoma.
Blokhin E, et al. J Cutan Pathol 40, 796-800 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cdkn2a includes H.sapiens CDKN2A and R.norvegicus Cdkn2a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 7 species)
Actinopterygii - bony fishes (1 transcript, 1 species)

 

 

 

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