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HomoloGene:123905. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DNM1,  H.sapiens
dynamin 1
    NP_001275668.1
864 aa
   DNM1,  P.troglodytes
dynamin 1
    XP_520289.3
864 aa
   DNM1,  M.mulatta
dynamin-1-like
    XP_002808141.1
862 aa
   DNM1,  C.lupus
dynamin 1
    NP_001124521.1
864 aa
   DNM1,  B.taurus
dynamin 1
    NP_001070288.1
856 aa
   Dnm1,  M.musculus
dynamin 1
    NP_034195.2
864 aa
   Dnm1,  R.norvegicus
dynamin 1
    NP_542420.1
851 aa
   DNM1,  G.gallus
dynamin 1
    XP_001233250.1
865 aa
   dnm1b,  D.rerio
dynamin 1b
    NP_001243747.1
858 aa
   shi,  D.melanogaster
shibire
    NP_001162767.1
883 aa
   AgaP_AGAP003018,  A.gambiae
AgaP_AGAP003018
    XP_003436355.1
862 aa
   dyn-1,  C.elegans
dyn-1
    NP_001024332.1
838 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
The shibire locus is characterized by its temperature-sensitive alleles, which are reversibly paralyzed by exposure to 29oC, but are essentially normal at 22oC (Grigliatti, Hall, Rosenbluth and Suzuki, 1973). Exposure of developing animals to the restrictive temperature for pulses of one to several hours leads to a plethora of developmental defects, which are specific for the stage treated (Poodry, Hall and Suzuki, 1973) (see shi1 allele record. Short exposures to restrictive temperatures at the time of delamination of the neuroblasts from the neurogenic ectoderm leads to excess neurogenesis at the expense of epidermogenesis, as seen in the neurogenic mutants (Poodry, 1990). (See FlyBase for complete description.)



Publications
Articles associated with genes and sequences of this homology group.

Membrane interaction of disease-related dynorphin A variants.
Björnerås J, et al. Biochemistry 52, 4157-67 (2013).
Identification of dynamin as a septin-binding protein.
Maimaitiyiming M, et al. Neurosci Lett 534, 322-6 (2013).
Activity-dependent phosphorylation of dynamin 1 at serine 857.
Xie W, et al. Biochemistry 51, 6786-96 (2012).
Using translational enhancers to increase transgene expression in Drosophila.
Pfeiffer BD, et al. Proc Natl Acad Sci U S A 109, 6626-31 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Drf_FH1 (pfam06346)
  Formin Homology Region 1.
GED (pfam02212)
  Dynamin GTPase effector domain.
Dynamin_M (pfam01031)
  Dynamin central region.
Dynamin_M (pfam01031)
  Dynamin central region.
Pro-rich (pfam15240)
  Proline-rich.
GED (cl02558)
  Dynamin GTPase effector domain.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dnm1 includes H.sapiens DNM1 and R.norvegicus Dnm1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (18 transcripts, 6 species)
Mammalia - mammals (12 transcripts, 11 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (13 transcripts, 10 species)
Arachnida - arachnids (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

 

 

 

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