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HomoloGene:496. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   TNF,  H.sapiens
tumor necrosis factor
233 aa
   TNF,  P.troglodytes
tumor necrosis factor
232 aa
   TNF,  M.mulatta
tumor necrosis factor
233 aa
   TNF,  C.lupus
tumor necrosis factor
233 aa
   TNF,  B.taurus
tumor necrosis factor
234 aa
   Tnf,  M.musculus
tumor necrosis factor
235 aa
   Tnf,  R.norvegicus
tumor necrosis factor
235 aa
   tnf,  X.tropicalis
tumor necrosis factor
227 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Migraine without aura, susceptibility to.
Dementia, vascular, susceptibility to.
Septic shock, susceptibility to.
Malaria, cerebral, susceptibility to.
Asthma, susceptibility to.
Malaria, cerebral, susceptibility to.

Articles associated with genes and sequences of this homology group.

TNF-α 308 G/A polymorphism and cervical intraepithelial neoplasia.
Rotar IC, et al. Anticancer Res 34, 373-8 (2014).
Superoxide release from contracting skeletal muscle in pulmonary TNF-α overexpression mice.
Zuo L, et al. Am J Physiol Regul Integr Comp Physiol 306, R75-81 (2014).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TNF (cl00147)
  Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tnf includes H.sapiens TNF and R.norvegicus Tnf.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (16 transcripts, 15 species)




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