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HomoloGene:31132. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   SPARC,  H.sapiens
secreted protein, acidic, cysteine-rich (osteonectin)
303 aa
   SPARC,  P.troglodytes
secreted protein, acidic, cysteine-rich (osteonectin)
303 aa
   SPARC,  M.mulatta
secreted protein, acidic, cysteine-rich (osteonectin)
467 aa
   SPARC,  C.lupus
secreted protein, acidic, cysteine-rich (osteonectin)
303 aa
   SPARC,  B.taurus
secreted protein, acidic, cysteine-rich (osteonectin)
304 aa
   Sparc,  M.musculus
secreted acidic cysteine rich glycoprotein
302 aa
   Sparc,  R.norvegicus
secreted protein, acidic, cysteine-rich (osteonectin)
301 aa
   SPARC,  G.gallus
secreted protein, acidic, cysteine-rich (osteonectin)
298 aa
   sparc,  X.tropicalis
secreted protein, acidic, cysteine-rich (osteonectin)
300 aa
   sparc,  D.rerio
secreted acidic cysteine rich glycoprotein
291 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Secreted protein acidic and rich in cysteine (SPARC)-null mice exhibit more uniform outflow.
Swaminathan SS, et al. Invest Ophthalmol Vis Sci 54, 2035-47 (2013).
SPARC fusion protein induces cellular adhesive signaling.
Cheng L, et al. PLoS One 8, e53202 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SPARC_Ca_bdg (pfam10591)
  Secreted protein acidic and rich in cysteine Ca binding region.
SPARC_EC (cd00252)
  SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
KAZAL_FS (cl00097)
  Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
EF-hand_8 (cl17302)
  EF-hand domain pair.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sparc includes H.sapiens SPARC and R.norvegicus Sparc.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (25 transcripts, 17 species)
Actinopterygii - bony fishes (22 transcripts, 12 species)
Aves - birds (5 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Hyperoartia - vertebrates (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Eudicotyledons - eudicots (1 transcript, 1 species)




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