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HomoloGene:392. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SOD1,  H.sapiens
superoxide dismutase 1, soluble
    NP_000445.1
154 aa
   SOD1,  P.troglodytes
superoxide dismutase 1, soluble
    NP_001009025.1
154 aa
   SOD1,  M.mulatta
superoxide dismutase 1, soluble
    NP_001027976.1
154 aa
   SOD1,  C.lupus
superoxide dismutase 1, soluble
    NP_001003035.1
153 aa
   SOD1,  B.taurus
superoxide dismutase 1, soluble
    NP_777040.1
152 aa
   Sod1,  M.musculus
superoxide dismutase 1, soluble
    NP_035564.1
154 aa
   Sod1,  R.norvegicus
superoxide dismutase 1, soluble
    NP_058746.1
154 aa
   SOD1,  G.gallus
superoxide dismutase 1, soluble
    NP_990395.1
154 aa
   sod1,  X.tropicalis
superoxide dismutase 1, soluble
    NP_001016252.1
151 aa
   sod1,  D.rerio
superoxide dismutase 1, soluble
    NP_571369.1
154 aa
   Sod,  D.melanogaster
Superoxide dismutase
    NP_001261700.1
167 aa
   CUSOD3,  A.gambiae
CUSOD3
    XP_311594.2
153 aa
   sod-1,  C.elegans
sod-1
    NP_001021956.1
180 aa
   sod-5,  C.elegans
sod-5
    NP_494779.1
178 aa
   SOD1,  S.cerevisiae
SOD1
    NP_012638.1
154 aa
   KLLA0E05567g,  K.lactis
KLLA0E05567g
    XP_454197.1
155 aa
   AGOS_AGL321W,  E.gossypii
AGOS_AGL321W
    NP_986346.2
154 aa
   sod1,  S.pombe
sod1
    NP_593163.1
154 aa
   MGG_02625,  M.oryzae
MGG_02625
    XP_003721165.1
158 aa
   NCU02133,  N.crassa
NCU02133
    XP_964291.2
154 aa
   CSD1,  A.thaliana
CSD1
    NP_001077494.1
152 aa
   Os03g0351500,  O.sativa
Os03g0351500
    NP_001050118.1
152 aa
   Os07g0665200,  O.sativa
Os07g0665200
    NP_001060564.1
152 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
The structural gene for Cu, Zn superoxide dismutase (SOD), a homodimer of 15,000 subunit molecular weight that contains two Cu++ and two Zn++ per molecule. Enzyme catalyzes the dismutation of the superoxide anion, O2-, to H2O2, which in turn is converted into H2O by catalase and peroxidases. Enzyme purified (Lee, Ayala and Misra, 1981); shows homology to homologous mammalian enzymes but does not crossreact with anti-bovine-erythrocyte-SOD antibodies; specific activity 1.5 times that of other species. (See FlyBase for complete description.)

H.sapiens
Amyotrophic lateral sclerosis, due to SOD1 deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Targeting SOD1 reduces experimental non–small-cell lung cancer.
Glasauer A, et al. J Clin Invest 124, 117-28 (2014).
Structural consequences of cysteinylation of Cu/Zn-superoxide dismutase.
Auclair JR, et al. Biochemistry 52, 6145-50 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cu-Zn_Superoxide_Dismutase (cl00891)
  Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sod1 includes H.sapiens SOD1 and R.norvegicus Sod1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (26 transcripts, 17 species)
Actinopterygii - bony fishes (17 transcripts, 12 species)
Amphibia - amphibians (5 transcripts, 2 species)
Ascidiacea - tunicates (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (24 transcripts, 12 species)
Arachnida - arachnids (13 transcripts, 2 species)
Branchiopoda - crustaceans (9 transcripts, 1 species)
Malacostraca - crustaceans (2 transcripts, 1 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (7 transcripts, 2 species)
Anthozoa - anthozoans (4 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (9 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (6 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (4 transcripts, 1 species)
Hirudinida - segmented worms (3 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (4 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (58 transcripts, 33 species)
Liliopsida - monocots (26 transcripts, 9 species)
Coniferopsida - conifers (15 transcripts, 3 species)
Bryopsida - mosses (3 transcripts, 1 species)
Isoetopsida - club-mosses (3 transcripts, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (8 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (3 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

 

 

 

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