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HomoloGene:2353. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SPTAN1,  H.sapiens
spectrin, alpha, non-erythrocytic 1
    NP_001123910.1
2477 aa
   SPTAN1,  P.troglodytes
spectrin, alpha, non-erythrocytic 1
    XP_003312345.1
2477 aa
   SPTAN1,  M.mulatta
spectrin, alpha, non-erythrocytic 1
    XP_002800011.1
2484 aa
   SPTAN1,  C.lupus
spectrin, alpha, non-erythrocytic 1
    XP_005625341.1
2489 aa
   SPTAN1,  B.taurus
spectrin, alpha, non-erythrocytic 1
    NP_001107628.1
2472 aa
   Sptan1,  M.musculus
spectrin alpha, non-erythrocytic 1
    NP_001171138.1
2477 aa
   Sptan1,  R.norvegicus
spectrin, alpha, non-erythrocytic 1
    NP_741984.2
2472 aa
   SPTAN1,  G.gallus
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
    NP_001036003.1
2477 aa
   sptan1,  X.tropicalis
spectrin, alpha, non-erythrocytic 1
    NP_001090674.1
2471 aa
   spna2,  D.rerio
spectrin alpha 2
    NP_001091958.1
2480 aa
   alpha-Spec,  D.melanogaster
alpha Spectrin
    NP_001261286.1
2457 aa
   AgaP_AGAP006686,  A.gambiae
AgaP_AGAP006686
    XP_316724.1
2417 aa
   spc-1,  C.elegans
spc-1
    NP_001257000.1
2432 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Epileptic encephalopathy, early infantile, 5.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Spectrin (pfam00435)
  Spectrin repeat.
efhand_Ca_insen (pfam08726)
  Ca2+ insensitive EF hand.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
EFhand_Ca_insen (pfam08726)
  Ca2+ insensitive EF hand.
Spectrin (cl02488)
  Spectrin repeat.
SH3 (cl17036)
  Src Homology 3 domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sptan1 includes H.sapiens SPTAN1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (21 transcripts, 11 species)
Mammalia - mammals (20 transcripts, 14 species)
Amphibia - amphibians (6 transcripts, 2 species)
Aves - birds (3 transcripts, 3 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 12 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (4 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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