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HomoloGene:7904. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PRNP,  H.sapiens
prion protein
    NP_898902.1
253 aa
   PRNP,  P.troglodytes
prion protein
    NP_001009093.1
253 aa
   PRNP,  M.mulatta
prion protein
    NP_001040617.1
253 aa
   PRNP,  B.taurus
prion protein
    NP_851358.2
264 aa
   Prnp,  M.musculus
prion protein
    NP_001265185.1
254 aa
   Prnp,  R.norvegicus
prion protein
    NP_036763.1
254 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Creutzfeldt-Jakob disease.
Gerstmann-Straussler disease.
Insomnia, fatal familial.
Huntington disease-like 1.
Prion disease with protracted course.



Publications
Articles associated with genes and sequences of this homology group.

De novo prion aggregates trigger autophagy in skeletal muscle.
Joshi-Barr S, et al. J Virol 88, 2071-82 (2014).
A novel prion disease associated with diarrhea and autonomic neuropathy.
Mead S, et al. N Engl J Med 369, 1904-14 (2013).
Characterization of early transient accumulation of PrP(Sc) in immune cells.
Elhelaly AE, et al. Biochem Biophys Res Commun 439, 340-5 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Prion_bPrPp (pfam11587)
  Major prion protein bPrPp - N terminal.
Prion_bPrPp (pfam11587)
  Major prion protein bPrPp - N terminal.
Prion (cl02493)
  Prion/Doppel alpha-helical domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prnp includes H.sapiens PRNP and R.norvegicus Prnp.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 16 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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